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Showing 1–7 of 7 results
Advanced filters: Author: Marcos F. Fondevila Clear advanced filters

  • p53 regulates signalling pathways involved in metabolic homeostasis. Here the authors show that O-GlcNAcylation of p53 in the liver plays a key role in the physiological regulation of glucose homeostasis, potentially via controlling the expression of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase.

    • Maria J. Gonzalez-Rellan
    • Marcos F. Fondevila
    • Ruben Nogueiras
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-21

  • p53 regulates lipid metabolism and fatty acid oxidation, and its inactivation promotes diet-induced liver steatosis. Here Porteiroet al. show that p53 deficiency leads to compensatory p63 upregulation, which, in turn, triggers endoplasmic reticulum stress through IKKβ activation, fatty acid synthesis and lipid accumulation.

    • Begoña Porteiro
    • Marcos F. Fondevila
    • Ruben Nogueiras
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-19

  • Folgueira et al. show that dopamine signalling in the lateral hypothalamic area and the zona incerta reduces body weight and increases energy expenditure by increasing brown adipose tissue thermogenesis in rodents. Weight loss and increased energy expenditure were also observed in patients treated with a dopamine receptor 2 agonist.

    • Cintia Folgueira
    • Daniel Beiroa
    • Ruben Nogueiras
    Research
    Nature Metabolism
    Volume: 1, P: 811-829

  • In this Consensus Statement, an international panel of experts present an overview of the latest developments in the field of cholangiocarcinoma. A set of consensus recommendations and research priorities is provided.

    • Jesus M. Banales
    • Pedro M. Rodrigues
    • Victor Lopez-Lopez
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 23, P: 65-96

  • Emerging studies suggest that p53 is an important regulator of energy metabolism, yet there is little known about the metabolic function of this tumor suppressor in the hypothalamus. Here, authors illustrate that p53, specifically in AgRP neurons, is required for adaptation to diet-induced obesity.

    • Mar Quiñones
    • Omar Al-Massadi
    • Ruben Nogueiras
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16