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Showing 1–3 of 3 results
Advanced filters: Author: Margaux Sevin Clear advanced filters

  • Myelofibrosis is a chronic degenerative disorder characterized by progressive bone marrow fibrosis. Here, the authors show that the chaperone HSP27 contributes to myelofibrosis via regulation of the JAK2/STAT5 pathway, and that antisense oligonucleotides targeting HSP27 are effective in two mouse models of the disease

    • Margaux Sevin
    • Lucia Kubovcakova
    • Aurélie de Thonel
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • In human β-thalassaemiaerythroblasts, HSP70 is sequestered in the cytoplasm by the excess of free α-globin chains and can no longer protect the master transcriptional factor of erythropoiesis GATA-1 from caspase-3 cleavage; transduction of a nuclear-targeted HSP70 or a caspase-3 uncleavable GATA-1 mutant restored maturation of erythropoiesis.

    • Jean-Benoît Arlet
    • Jean-Antoine Ribeil
    • Geneviève Courtois
    Research
    Nature
    Volume: 514, P: 242-246