Nature Search

Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS

Noncoding transcripts contribute to the adaptation of cellular processes to oxygen levels. Here the authors characterize a hypoxia responsive lncRNA lincNORS and show that it has a role in cellular sterol homeostasis.

Xue Wu
Cristina M. Niculite
Mircea Ivan
ResearchOpen Access21 Sept 2020
Nature Communications

Volume: 11, P: 1-17
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Associations of adipose insulin resistance index with pancreatic β cell function (inverse) and glucose excursion (positive) in young Japanese women

Satomi Minato-Inokawa
Mari Honda
Keisuke Fukuo
ResearchOpen Access10 Aug 2024
Scientific Reports

Volume: 14, P: 1-7
Adipose tissue insulin resistance index was inversely associated with gluteofemoral fat and skeletal muscle mass in Japanese women

Satomi Minato-Inokawa
Mari Honda
Keisuke Fukuo
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-8
The different associations of serum gamma-glutamyl transferase and alanine aminotransferase with insulin secretion, β-cell function, and insulin resistance in non-obese Japanese

Satomi Minato-Inokawa
Ayaka Tsuboi-Kaji
Keisuke Fukuo
ResearchOpen Access20 Aug 2024
Scientific Reports

Volume: 14, P: 1-8
Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

Narcolepsy has genetic and environmental risk factors, but the specific genetic risk loci and interaction with environmental triggers are not well understood. Here, the authors identify genetic loci for narcolepsy, suggesting infection as a trigger and dendritic and helper T cell involvement.

Hanna M. Ollila
Eilon Sharon
Emmanuel J. Mignot
ResearchOpen Access15 May 2023
Nature Communications

Volume: 14, P: 1-13
The genome sequence and structure of rice chromosome 1

Takuji Sasaki
Takashi Matsumoto
Takashi Gojobori
ResearchOpen Access21 Nov 2002
Nature

Volume: 420, P: 312-316
Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor

Tetsuya Ohtaki
Yasushi Shintani
Masahiko Fujino
Research31 May 2001
Nature

Volume: 411, P: 613-617
Association between serum leptin concentrations and homeostasis model assessment-insulin resistance of 2.5 and higher in normal weight Japanese women

Satomi Minato-Inokawa
Yuuna Hayashida
Keisuke Fukuo
ResearchOpen Access22 May 2023
Scientific Reports

Volume: 13, P: 1-7
Associations of alanine aminotransferase/aspartate aminotransferase with insulin resistance and β-cell function in women

Satomi Minato-Inokawa
Ayaka Tsuboi-Kaji
Keisuke Fukuo
ResearchOpen Access15 May 2023
Scientific Reports

Volume: 13, P: 1-7
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Reduced gluteofemoral (subcutaneous) fat mass in young Japanese women with family history of type 2 diabetes: an exploratory analysis

Mari Honda
Ayaka Tsuboi
Keisuke Fukuo
ResearchOpen Access22 Jul 2022
Scientific Reports

Volume: 12, P: 1-8
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Elevated 1 h post-load plasma glucose associates with decreased serum lipoprotein lipase in youth and decreased leg fat mass in midlife

Satomi Minato-Inokawa
Ayaka Tsuboi-Kaji
Keisuke Fukuo
ResearchOpen Access27 Oct 2025
Scientific Reports

Volume: 15, P: 1-9
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Prognostic impact of ACTN4 gene copy number alteration in hormone receptor-positive, HER2-negative, node-negative invasive breast carcinoma

Teppei Sugano
Masayuki Yoshida
Tesshi Yamada
ResearchOpen Access08 Apr 2020
British Journal of Cancer

Volume: 122, P: 1811-1817
Distinctive duodenal microbiomes and bile acid profiles in duodenal tumor patients revealed by prospective observational study

Yoko Kubosawa
Tomohisa Sujino
Takanori Kanai
ResearchOpen Access12 Aug 2024
Scientific Reports

Volume: 14, P: 1-11
Low leg fat mass is associated with low insulin sensitivity, inflammatory markers, and β-cell dysfunction in non-obese Japanese people

Satomi Minato-Inokawa
Mari Honda
Keisuke Fukuo
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-9
Long-read sequencing identifies GGC repeat expansions in NOTCH2NLC associated with neuronal intranuclear inclusion disease

Long-read sequencing identifies a GGC repeat expansion in NOTCH2NLC that is associated with neuronal intranuclear inclusion disease, a progressive neurodegenerative disorder. The expansion results in abnormal anti-sense transcripts that could contribute to disease pathogenesis.

Jun Sone
Satomi Mitsuhashi
Gen Sobue
Research22 Jul 2019
Nature Genetics

Volume: 51, P: 1215-1221
Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg

Hiroshi Fukuhara
Mari Masvuda
Yoshinori Murakami
Research18 Sept 2003
Oncogene

Volume: 22, P: 6160-6165
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Association of anemia with hyperadiponectinemia in oldest–old Japanese women who resided at home alone without wheelchair use

Mari Honda
Satomi Minato-Inokawa
Keisuke Fukuo
ResearchOpen Access10 Nov 2024
Scientific Reports

Volume: 14, P: 1-13
Synergic interaction between ritodrine and magnesium sulfate on the occurrence of critical neonatal hyperkalemia: A Japanese nationwide retrospective cohort study

Yukari Yada
Akihide Ohkuchi
Mariko Hida
ResearchOpen Access08 May 2020
Scientific Reports

Volume: 10, P: 1-13
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Organomediated polymerization

Communications Chemistry is pleased to introduce a Collection of articles focused on organomediated polymerization. Here, the Guest Editors highlight the themes within and look towards the future of this research field.

Satoshi Honda
Karin Odelius
Haritz Sardon
EditorialOpen Access21 Mar 2024
Communications Chemistry

Volume: 7, P: 1-2

Search

Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS

Mapping the human genetic architecture of COVID-19

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

DOCK2 is involved in the host genetics and biology of severe COVID-19

Blood DNA virome associates with autoimmune diseases and COVID-19

Associations of adipose insulin resistance index with pancreatic β cell function (inverse) and glucose excursion (positive) in young Japanese women

Adipose tissue insulin resistance index was inversely associated with gluteofemoral fat and skeletal muscle mass in Japanese women

The different associations of serum gamma-glutamyl transferase and alanine aminotransferase with insulin secretion, β-cell function, and insulin resistance in non-obese Japanese

Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

The genome sequence and structure of rice chromosome 1

Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor

Association between serum leptin concentrations and homeostasis model assessment-insulin resistance of 2.5 and higher in normal weight Japanese women

Associations of alanine aminotransferase/aspartate aminotransferase with insulin resistance and β-cell function in women

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Reduced gluteofemoral (subcutaneous) fat mass in young Japanese women with family history of type 2 diabetes: an exploratory analysis

A second update on mapping the human genetic architecture of COVID-19

Elevated 1 h post-load plasma glucose associates with decreased serum lipoprotein lipase in youth and decreased leg fat mass in midlife

Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Prognostic impact of ACTN4 gene copy number alteration in hormone receptor-positive, HER2-negative, node-negative invasive breast carcinoma

Distinctive duodenal microbiomes and bile acid profiles in duodenal tumor patients revealed by prospective observational study

Low leg fat mass is associated with low insulin sensitivity, inflammatory markers, and β-cell dysfunction in non-obese Japanese people

Long-read sequencing identifies GGC repeat expansions in NOTCH2NLC associated with neuronal intranuclear inclusion disease

Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg

Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Association of anemia with hyperadiponectinemia in oldest–old Japanese women who resided at home alone without wheelchair use

Synergic interaction between ritodrine and magnesium sulfate on the occurrence of critical neonatal hyperkalemia: A Japanese nationwide retrospective cohort study

Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Organomediated polymerization

Search

Quick links

Search

Filter By:

Search

Quick links