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The main protease (M^pro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII

SARS-CoV-2 main protease (Mpro) directly activates coagulation by cleaving factors VII and XII, showing a broader protease specificity and revealing a novel mechanism linking COVID-19 infection to thrombosis.

Anna Pagotto
Federico Uliana
Vincenzo De Filippis
ResearchOpen Access01 Aug 2025
Communications Biology

Volume: 8, P: 1-16

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The main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII

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The main protease (M^pro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII