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Advanced filters: Author: Mariana Angulo-Aguado Clear advanced filters

Macrophages harness hepatocyte glutamate to boost liver regeneration

Glutamate metabolically reprograms bone-marrow-derived macrophages, stabilizing HIF1α, which transcriptionally activates WNT3 to promote YAP1-dependent hepatocyte proliferation, boosting liver regeneration.

María del Mar Rigual
Mariana Angulo-Aguado
Nabil Djouder
Research26 Mar 2025
Nature

Volume: 641, P: 1005-1016
p53 protein degradation redefines the initiation mechanisms and drives transitional mutations in colorectal cancer

Loss of the tumor suppressor p53 facilitates the malignant progression of colorectal cancer (CRC) following the initial transformation. Here, the authors report that p53 protein degradation triggered by the MYC/URI axis, is an early event essential for tumor initiation in Wnt activation-based CRC models.

Irene Herranz-Montoya
Mariana Angulo-Aguado
Nabil Djouder
ResearchOpen Access26 Apr 2025
Nature Communications

Volume: 16, P: 1-20
Next-generation sequencing of host genetics risk factors associated with COVID-19 severity and long-COVID in Colombian population

Mariana Angulo-Aguado
Juan Camilo Carrillo-Martinez
Oscar Ortega-Recalde
ResearchOpen Access11 Apr 2024
Scientific Reports

Volume: 14, P: 1-17

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