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Autophagy-regulated mitochondrial inheritance controls early CD8⁺ T cell fate commitment

Borsa et al. show that asymmetric T cell division after activation requires autophagy to promote mitochondrial turnover, with T cells inheriting older mitochondria showing decreased degradation, reduced memory potential and altered metabolism.

Mariana Borsa
Ana Victoria Lechuga-Vieco
Anna Katharina Simon
ResearchOpen Access19 Dec 2025
Nature Cell Biology

Volume: 28, P: 66-81
Autophagy acts as a brake on obesity-related fibrosis by controlling purine nucleoside signalling

The study shows that autophagy in fat cells protects against obesity-induced fibrosis. Autophagy limits the release of purines, a metabolic product, that signals to immune cells to initiate the fibrosis. Purines might be a potential target for reducing tissue fibrosis.

Klara Piletic
Amir H. Kayvanjoo
Anna Katharina Simon
ResearchOpen Access17 Oct 2025
Nature Communications

Volume: 16, P: 1-17
Getting to the (germinal) centre of SARS-CoV-2

Felix Clemens Richter
Mariana Borsa
Research Highlights11 Aug 2020
Nature Reviews Immunology

Volume: 20, P: 590
Attacking the defence: SARS-CoV-2 can infect immune cells

Mariana Borsa
Julie M. Mazet
Research Highlights21 Aug 2020
Nature Reviews Immunology

Volume: 20, P: 592
Heterologous immunity: innate function of memory CD4⁺ T cells

A preprint by Rakebrandt, Yassini et al. investigates the role of CD4⁺ T helper cells in heterologous immunity, identifying a population of memory cells that have pro-inflammatory function in a T cell receptor-independent manner.

Mariana Borsa
Carmen Gerlach
Research Highlights26 Jul 2023
Nature Reviews Immunology

Volume: 23, P: 544
Sensing extracellular ATP boosts memory T cell commitment

A recent preprint describes a role for sensing of extracellular ATP through P2RX7 in the formation of memory T cells.

Dingxi Zhou
Mariana Borsa
Research Highlights13 Jul 2021
Nature Reviews Immunology

Volume: 21, P: 473
Asymmetric cell division shapes naive and virtual memory T-cell immunity during ageing

Asymmetrical cell division helps to maintain cellular heterogeneity in the T cell compartment. Here the authors examine the differential immune responses built by naive and virtual memory T cells from young and aged individuals, and explore the effect of mTOR inhibition on asymmetrical cell division and memory formation.

Mariana Borsa
Niculò Barandun
Annette Oxenius
ResearchOpen Access11 May 2021
Nature Communications

Volume: 12, P: 1-12
Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation

Autophagy is known to impact CD4+ T cell proliferation but the identity of autophagosomal components remain unclear. Here the authors leverage a transgenic mouse model to assess the autophagosomal compartment and identify interleukin-7 receptor-α as a key cargo in proliferating CD4+ T cells.

Dingxi Zhou
Mariana Borsa
Anna Katharina Simon
ResearchOpen Access02 Sept 2022
Nature Communications

Volume: 13, P: 1-15

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