How DNA glycosylases repair base lesions within nucleosomes remains unclear. Here, the authors determine the cryo-EM structure of 8-oxoguanine-DNA glycosylase 1 bound to an 8-oxoguanine lesion in a nucleosome core particle, thereby providing insights into base excision repair within chromatin.
- Mengtian Ren
- Fabian Gut
- Chuanzheng Zhou