IL4 and glucocorticoids elicit a homeostatic phenotype in macrophages. Here the authors show that these disparate stimuli yield converging epigenomic and transcriptomic changes, enacted by transcription factors KLF4 and the glucocorticoid receptor, and integrated by their shared coregulator GRIP1.
- Dinesh K. Deochand
- Marija Dacic
- Inez Rogatsky