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Showing 1–6 of 6 results
Advanced filters: Author: Marilena Hadjidemetriou Clear advanced filters

  • The nanoparticle protein corona has potential to enrich disease monitoring and detect biomarkers. Here, the authors report on a nano-omics investigation of changes in plasma and tumour tissue proteins associated with glioblastoma and demonstrate biomarker discovery in mouse models and patient cohorts.

    • Xinming Liu
    • Hanan Abmanhal-Masarweh
    • Marilena Hadjidemetriou
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Abumanhal-Masarweh et al. profile plasma proteomes of cancer patients during radiotherapy and detect acute changes in inflammatory and immune pathways. Correlating these changes with toxicity data enables identification of a predictive signature for radiation-induced toxicities.

    • Hanan Abumanhal-Masarweh
    • Salam A. Assi
    • Marilena Hadjidemetriou
    ResearchOpen Access
    Communications Medicine
    P: 1-14

  • Understanding how complement proteins bind to nanoparticles and participate in their surface 'corona' can provide further insight into the relevance of the protein corona concept in medicine.

    • Marilena Hadjidemetriou
    • Kostas Kostarelos
    News & Views
    Nature Nanotechnology
    Volume: 12, P: 288-290

  • Assessment of the health risks of exposure to anthropogenic nanomaterials is crucial to maximize their potential applications. This double-blind, randomized controlled study in healthy humans evaluates the impact of inhalation of graphene oxide nanosheets on acute pulmonary and cardiovascular functions.

    • Jack P. M. Andrews
    • Shruti S. Joshi
    • Mark R. Miller
    ResearchOpen Access
    Nature Nanotechnology
    Volume: 19, P: 705-714

  • Nanoparticles (NPs) administered in the human body will undergo rapid surface modification upon contact with biological fluids driven by their interfacial interaction with a diverse range of biomolecules. Such spontaneous self-assembly and adsorption of proteins and other biomolecules onto the NP surface constitute what is commonly known as the protein or biomolecule corona. This surface biotransformation of the NPs modulates their biological interactions and impact on physiological systems and can influence their overall pharmacological profile. Here, we comment on how the initially considered ‘nuisance’ of the in vivo corona formation can now be considered a nanoparticle engineering tool for biomedical use, such as in endogenous tissue targeting, personalized biomarker discovery and immunomodulation.

    • Marilena Hadjidemetriou
    • Morteza Mahmoudi
    • Kostas Kostarelos
    Comments & Opinion
    Nature Reviews Materials
    Volume: 9, P: 219-222

  • Liquid biopsy assays of diverse cancer-associated molecular alterations in blood, including genomic, epigenomic, transcriptomic, proteomic and metabolomics changes, offer considerable opportunities for early detection of cancer as well as improved management of the disease. In this Perspective, the authors review key advances in liquid biopsy-based multi-omics approaches for biomarker discovery. They also introduce the ‘nano-omics’ paradigm, whereby nanotechnology tools are used to capture and enrich various cancer-derived analytes from biofluids for subsequent omics analyses, with the aim of developing novel biomarker panels for early cancer detection.

    • Lois Gardner
    • Kostas Kostarelos
    • Marilena Hadjidemetriou
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 19, P: 551-561