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Showing 1–5 of 5 results
Advanced filters: Author: Marina Chekulaeva Clear advanced filters

  • Marina Chekulaeva describes the experiments that showed that microRNAs cause degradation of their target mRNAs.

    • Marina Chekulaeva
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 24, P: 164

  • The function of GW182 proteins in miRNA-mediated gene silencing has been unclear. Studies in human and fly cells now identify tryptophan-containing motifs as important repressive elements. These motifs, which are dispersed throughout GW182 proteins, function additively by recruiting deadenylase complexes to repress both poly(A)+ and poly(A)− mRNAs, suggesting that recruitment, in addition to catalyzing deadenylation, also mediates translational repression.

    • Marina Chekulaeva
    • Hansruedi Mathys
    • Witold Filipowicz
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 1218-1226

  • Subcellular localization of RNAs and proteins is important for polarized cells such as neurons. Here the authors differentiate mouse embryonic stem cells into neurons, and analyze the local transcriptome, proteome, and translated transcriptome in their cell bodies and neurites, providing a unique resource for future studies on neuronal polarity.

    • Alessandra Zappulo
    • David van den Bruck
    • Marina Chekulaeva
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • The subcellular localization of numerous mRNAs has been demonstrated. This Review presents the different means of mRNA localization described and discusses how they can account for the widespread occurrence of this phenomenon.

    • Marina Chekulaeva
    Reviews
    Nature Cell Biology
    Volume: 26, P: 1037-1046