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Showing 1–4 of 4 results

Advanced filters: Author: Marine Barthez Clear advanced filters

M1BP is an essential transcriptional activator of oxidative metabolism during Drosophila development

The transcriptional regulation of mitochondrial oxidative phosphorylation gene expression is poorly understood. Using the developing Drosophila flight muscle, the authors identify the transcription factor M1BP as a new major regulator of this process.

Gabriela Poliacikova
Marine Barthez
Andrew J. Saurin
ResearchOpen Access02 Jun 2023
Nature Communications

Volume: 14, P: 1-20
UPR^mt controls the mesenchymal-to-epithelial transition

The mitochondrial unfolded protein response (UPR^mt) is a transcriptional program that is activated in cells experiencing mitochondrial stress and that helps to return to proteostasis and improve stress resistance. Ying et al. reveal that the UPR^mt controls the mesenchymal-to-epithelial transition during the acquisition of pluripotency.

Marine Barthez
Danica Chen
News & Views09 Apr 2025
Nature Metabolism

Volume: 7, P: 871-872
An NAD⁺-dependent metabolic checkpoint regulates hematopoietic stem cell activation and aging

Song et al. show that in young mice CD38 supports hematopoietic stem cell (HSC) proliferation by regulating Ca²⁺ signaling and mitochondrial activity. Conversely, the upregulation of CD38 during aging causes dysregulation of NAD metabolism, mitochondrial stress and HSC dysfunction.

Zehan Song
Sang Hee Park
Danica Chen
Research23 Jul 2024
Nature Aging

Volume: 4, P: 1384-1393
Human ZKSCAN3 and Drosophila M1BP are functionally homologous transcription factors in autophagy regulation

Marine Barthez
Mathilde Poplineau
Andrew J. Saurin
ResearchOpen Access15 Jun 2020
Scientific Reports

Volume: 10, P: 1-14