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Showing 1–4 of 4 results
Advanced filters: Author: Mario Manto Clear advanced filters

  • Transient overexpression of the transcription factors NKX2-1 and PAX8 in a murine cell model is shown to direct the differentiation of embryonic stem cells towards a thyroid follicular cell lineage; the resulting three-dimensional thyroid follicles created by subsequent thyrotropin treatment show hallmarks of thyroid function in vitro and rescue thyroid function in vivo when transplanted into athyroid mice, adding to our understanding of the molecular mechanisms underlying thyroid development.

    • Francesco Antonica
    • Dominika Figini Kasprzyk
    • Sabine Costagliola
    Research
    Nature
    Volume: 491, P: 66-71

  • In this study, the authors show that Celsr3 and Fzd3 interact in motor neurons to cooperatively direct axon guidance to target muscles in the periphery. In addition, they find that loss of Celsr3 or Fzd3 function also impairs axonal responses to ephrinA reverse, attractive signaling, suggesting a functional interaction between these guidance pathways.

    • Guoliang Chai
    • Libing Zhou
    • Fadel Tissir
    Research
    Nature Neuroscience
    Volume: 17, P: 1171-1179

  • In this Review, the authors discuss recessive ataxias with ganglionopathy or polyneuropathy — particularly Friedreich ataxia and RFC1-associated cerebellar ataxia, neuropathy, vestibular areflexia syndrome — including the possible shared pathogenic mechanisms between these diseases and therapeutic advances.

    • Marie Beaudin
    • Mario Manto
    • Nicolas Dupre
    Reviews
    Nature Reviews Neurology
    Volume: 18, P: 257-272