Proteinuria often precedes any detectable decline in renal filtration function and is a strong and independent predictor of increased risk for all-cause and cardiovascular mortality. In this Review, Dr Agrawal and colleagues examine potential pathophysiologic mechanisms to explain simultaneous renal and cardiac disease, as well as therapeutic strategies for amelioration of proteinuria.
- Varun Agrawal
- Victor Marinescu
- Peter A. McCullough
