Nature Search

A bestiary of non-linear functions for growth analysis

C. E. Timothy Paine
Toby Marthews
Lindsay Turnbull
ResearchOpen Access15 Nov 2010
Nature Precedings

P: 1
Predictive chemoproteomics and functional validation reveal Coeae6g-mediated insecticide cross-resistance in the malaria vector Anopheles gambiae

The evolution of insecticide resistance in the major malaria vector, Anopheles gambiae, remains an important issue in sustainable malaria control in Africa. Here, the authors present a framework for identifying resistance mechanisms before they arise in field mosquito populations. The findings have implications for public health surveillance and vector control.

Sofia Balaska
Linda Grigoraki
Hanafy M. Ismail
ResearchOpen Access28 Nov 2025
Nature Communications

Volume: 16, P: 1-13
Calcium signals in neurons

Mark N. Rand
Trese Leinders-Zufall
Jeffery D. Kocsis
Research22 Sept 1994
Nature

Volume: 371, P: 291-292
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Doughnut-shaped structure of a bacterial muramidase revealed by X-ray crystallography

Andy-Mark W. H. Thunnissen
Arnoud J. Dijkstra
Bauke W. Dijkstra
Research24 Feb 1994
Nature

Volume: 367, P: 750-753
A molecular cell atlas of mouse lemur, an emerging model primate

Together with a companion paper, the generation of a transcriptomic atlas for the mouse lemur and analyses of example cell types establish this animal as a molecularly tractable primate model organism.

Antoine de Morree
Iwijn De Vlaminck
Mark A. Krasnow
ResearchOpen Access30 Jul 2025
Nature

Volume: 644, P: 173-184
Mouse lemur cell atlas informs primate genes, physiology and disease

Together with an accompanying paper presenting a transcriptomic atlas of the mouse lemur, interrogation of the atlas provides a rich body of data to support the use of the organism as a model for primate biology and health.

Camille Ezran
Shixuan Liu
Mark A. Krasnow
ResearchOpen Access30 Jul 2025
Nature

Volume: 644, P: 185-196
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Benchmarking cell type and gene set annotation by large language models with AnnDictionary

Cell type labelling in single-cell datasets remains a major bottleneck. Here, the authors present AnnDictionary, an open-source toolkit that enables atlas-scale analysis and provides the first benchmark of LLMs for de novo cell type annotation from marker genes, showing high accuracy at low cost.

George Crowley
Robert C. Jones
Stephen R. Quake
ResearchOpen Access28 Oct 2025
Nature Communications

Volume: 16, P: 1-14
Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors

Application of a nanopore sequencing workflow for real-time analysis of brain tumors results in molecular classification within a 30-minute intraoperative window, followed by comprehensive profiling within 24 hours.

Areeba Patel
Kirsten Göbel
Felix Sahm
ResearchOpen Access25 Mar 2025
Nature Medicine

Volume: 31, P: 1567-1577
Antimalarial activity of primaquine operates via a two-step biochemical relay

Primaquine (PQ) is a widely used anti-malaria drug, but its mechanism of action is unclear. Here, Camarda et al. show that PQ’s activity against liver and sexual Plasmodium stages depends on generation of hydroxylated-PQ metabolites (OH-PQm), which, undergoing further reactions, results in production of H₂O₂.

Grazia Camarda
Piyaporn Jirawatcharadech
Giancarlo A. Biagini
ResearchOpen Access19 Jul 2019
Nature Communications

Volume: 10, P: 1-9
Chlorfenapyr metabolism by mosquito P450s associated with pyrethroid resistance identifies potential activation markers

Cristina Yunta
Jocelyn M. F. Ooi
Mark J. I. Paine
ResearchOpen Access29 Aug 2023
Scientific Reports

Volume: 13, P: 1-9
From bench to business: Career opportunities in biotechnology

Analysis shows that careers abound for PhDs outside academia in the 1990s.

Mark D. Dibner
Cynthia J. Sollod
Special Features01 Oct 1997
Nature Biotechnology

Volume: 15, P: 958-960
An organism-wide atlas of hormonal signaling based on the mouse lemur single-cell transcriptome

Endocrinologists have traditionally focused on studying one hormone or organ system at a time. Here the authors use transcriptomic data from the mouse lemur to globally characterize primate hormonal signaling, describing hormone sources and targets, identifying conserved and primate specific regulation, and elucidating principles of the network.

Shixuan Liu
Camille Ezran
James E. Ferrell Jr.
ResearchOpen Access11 Mar 2024
Nature Communications

Volume: 15, P: 1-27
Adversarial domain translation networks for integrating large-scale atlas-level single-cell datasets

An adversarial domain translation framework is presented for scalable integration of single-cell atlases across samples, technical platforms, data modalities and species.

Jia Zhao
Gefei Wang
Can Yang
Research30 May 2022
Nature Computational Science

Volume: 2, P: 317-330
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss

Volumetric muscle loss leads to functional muscle impairment, and current stem cell-based treatments show limited efficacy. Here, the authors generate a stem cell scaffold, implant it in mice, and show that an exercise regimen enhances innervation and restoration of muscle function in mice.

Marco Quarta
Melinda Cromie
Thomas A. Rando
ResearchOpen Access20 Jun 2017
Nature Communications

Volume: 8, P: 1-17
Current smoking with or without chronic bronchitis is independently associated with goblet cell hyperplasia in healthy smokers and COPD subjects

Victor Kim
Stephanie Jeong
Prescott G. Woodruff
ResearchOpen Access18 Nov 2020
Scientific Reports

Volume: 10, P: 1-8
Book reviews

Mark J I Paine
Books & Arts01 Nov 1992
Heredity

Volume: 69, P: 484-485
Automated, parallel mass spectrometry imaging and structural identification of lipids

An automated method coupling tandem mass spectrometry with high-resolution mass spectrometry imaging simultaneously reveals both the molecular structure of lipids and their spatial locations in tissue.

Shane R. Ellis
Martin R. L. Paine
Ron M. A. Heeren
Research21 May 2018
Nature Methods

Volume: 15, P: 515-518
New insecticide screening platforms indicate that Mitochondrial Complex I inhibitors are susceptible to cross-resistance by mosquito P450s that metabolise pyrethroids

Rosemary S. Lees
Hanafy M. Ismail
Mark J. I. Paine
ResearchOpen Access01 Oct 2020
Scientific Reports

Volume: 10, P: 1-10
Combining conventional QTL analysis and whole-exome capture-based bulk-segregant analysis provides new genetic insights into tuber sprout elongation and dormancy release in a diploid potato population

Sanjeev Kumar Sharma
Karen McLean
Glenn J. Bryan
ResearchOpen Access30 Jul 2021
Heredity

Volume: 127, P: 253-265
Immunologic mechanisms of seasonal influenza vaccination administered by microneedle patch from a randomized phase I trial

Nadine G. Rouphael
Lilin Lai
Mark R. Prausnitz
ResearchOpen Access14 Jul 2021
npj Vaccines

Volume: 6, P: 1-9
Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort

Kristopher Opron
Lesa A. Begley
Yvonne J. Huang
ResearchOpen Access05 Feb 2021
npj Biofilms and Microbiomes

Volume: 7, P: 1-10
Author Correction: Chlorfenapyr metabolism by mosquito P450s associated with pyrethroid resistance identifies potential activation markers

Cristina Yunta
Jocelyn M. F. Ooi
Mark J. I. Paine
Amendments and CorrectionsOpen Access16 Nov 2023
Scientific Reports

Volume: 13, P: 1
A high-throughput HPLC method for simultaneous quantification of pyrethroid and pyriproxyfen in long-lasting insecticide-treated nets

Kyle J. Walker
Christopher T. Williams
Hanafy M. Ismail
ResearchOpen Access11 Jun 2022
Scientific Reports

Volume: 12, P: 1-12
Tandem duplication of a genomic region encoding glutathione S-transferase epsilon-2 and -4 genes in DDT-resistant Anopheles stephensi strain from India

Cherry L. Dykes
Gunjan Sharma
Om P. Singh
ResearchOpen Access25 Oct 2022
Scientific Reports

Volume: 12, P: 1-14

Search

A bestiary of non-linear functions for growth analysis

Predictive chemoproteomics and functional validation reveal Coeae6g-mediated insecticide cross-resistance in the malaria vector Anopheles gambiae

Calcium signals in neurons

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Doughnut-shaped structure of a bacterial muramidase revealed by X-ray crystallography

A molecular cell atlas of mouse lemur, an emerging model primate

Mouse lemur cell atlas informs primate genes, physiology and disease

A second update on mapping the human genetic architecture of COVID-19

Benchmarking cell type and gene set annotation by large language models with AnnDictionary

Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors

Antimalarial activity of primaquine operates via a two-step biochemical relay

Chlorfenapyr metabolism by mosquito P450s associated with pyrethroid resistance identifies potential activation markers

From bench to business: Career opportunities in biotechnology

An organism-wide atlas of hormonal signaling based on the mouse lemur single-cell transcriptome

Adversarial domain translation networks for integrating large-scale atlas-level single-cell datasets

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss

Current smoking with or without chronic bronchitis is independently associated with goblet cell hyperplasia in healthy smokers and COPD subjects

Book reviews

Automated, parallel mass spectrometry imaging and structural identification of lipids

New insecticide screening platforms indicate that Mitochondrial Complex I inhibitors are susceptible to cross-resistance by mosquito P450s that metabolise pyrethroids

Combining conventional QTL analysis and whole-exome capture-based bulk-segregant analysis provides new genetic insights into tuber sprout elongation and dormancy release in a diploid potato population

Immunologic mechanisms of seasonal influenza vaccination administered by microneedle patch from a randomized phase I trial

Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort

Author Correction: Chlorfenapyr metabolism by mosquito P450s associated with pyrethroid resistance identifies potential activation markers

A high-throughput HPLC method for simultaneous quantification of pyrethroid and pyriproxyfen in long-lasting insecticide-treated nets

Tandem duplication of a genomic region encoding glutathione S-transferase epsilon-2 and -4 genes in DDT-resistant Anopheles stephensi strain from India

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