Nature Search

Zylka et al. reply

Mark J. Zylka
Ben D. Philpot
Ian F. King
Research06 Aug 2014
Nature

Volume: 512, P: E2
Topoisomerases facilitate transcription of long genes linked to autism

Reducing topoisomerase activity in mouse and human neurons is found to reduce the expression of long genes by impairing transcription elongation: among genes affected are numerous high-confidence candidates for autism spectrum disorder.

Ian F. King
Chandri N. Yandava
Mark J. Zylka
Research28 Aug 2013
Nature

Volume: 501, P: 58-62
Compact Calm1 promoter enables AAV mediated neuron-targeted expression in human iPSC-derived brain organoids

Ina Klockner
Meghana Yeturi
Mark J. Zylka
ResearchOpen Access24 Dec 2025
Scientific Reports

Volume: 15, P: 1-9
Emerging Roles for Ectonucleotidases in Pain-Sensing Neurons

Sarah E Street
Mark J Zylka
Research30 Nov 2010
Neuropsychopharmacology

Volume: 36, P: 358
Cas9 gene therapy for Angelman syndrome traps Ube3a-ATS long non-coding RNA

Genomic integration of an adeno-associated virus vector in a mouse model of Angelman syndrome unsilences paternal Ube3a and rescues anatomical and behavioural phenotypes, suggesting a pathway towards the treatment of this neurodevelopmental disorder.

Justin M. Wolter
Hanqian Mao
Mark J. Zylka
Research21 Oct 2020
Nature

Volume: 587, P: 281-284
Multi-targeting zinc finger nuclease vector unsilences paternal UBE3A in a mouse model of Angelman syndrome

Hannah O. Bazick
Lucas M. James
Mark J. Zylka
ResearchOpen Access25 Nov 2025
Gene Therapy

P: 1-11
Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch

Qin Liu
Sophia Vrontou
David J Anderson
Research08 Jul 2007
Nature Neuroscience

Volume: 10, P: 946-948
Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration

This study presents gene expression responses of cultured brain cells to hundreds of chemicals found in the environment and in food. The authors identified chemicals that induce transcriptomic profiles that overlap those seen in human brains affected with autism, aging, and neurodegeneration.

Brandon L. Pearson
Jeremy M. Simon
Mark J. Zylka
ResearchOpen Access31 Mar 2016
Nature Communications

Volume: 7, P: 1-12
Single-cell transcriptomic analysis of mouse neocortical development

The authors perform single-cell RNA-seq of the mouse neocortex at an embryonic time point and at birth, and identify new and known cell types, and cell relatedness within and across age. These data serve as a resource to understand brain development and the cellular origins of brain diseases.

Lipin Loo
Jeremy M. Simon
Mark J. Zylka
ResearchOpen Access11 Jan 2019
Nature Communications

Volume: 10, P: 1-11
Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration

Topoisomerase 1 (TOP1) relieves DNA torsional stress during transcription and facilitates the expression of long neuronal genes. Here we show that deletion of Top1 in excitatory neurons leads to early onset neurodegeneration that is partially dependent on p53/PARP1 activation and NAD⁺ depletion.

Giulia Fragola
Angela M. Mabb
Mark J. Zylka
ResearchOpen Access23 Apr 2020
Nature Communications

Volume: 11, P: 1-13
scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy

Although the hedgehog (HH) pathway is known to be deregulated in medulloblastoma, inhibitors of the pathway have shown disappointing clinical benefit. Using single-cell sequencing in a mouse model of the disease, the authors show that the response to the HH pathway inhibitor vismodegib is cell-type specific.

Jennifer Karin Ocasio
Benjamin Babcock
Timothy R. Gershon
ResearchOpen Access20 Dec 2019
Nature Communications

Volume: 10, P: 1-17
Stimulating Wnt signaling reveals context-dependent genetic effects on gene regulation in primary human neural progenitors

Matoba, Le, Valone et al. characterized context-dependent genetic effects on gene regulatory activity during Wnt stimulation, finding that genetic variant function during neurodevelopment patterning can lead to differences in adult brain traits.

Nana Matoba
Brandon D. Le
Jason L. Stein
Research30 Sept 2024
Nature Neuroscience

Volume: 27, P: 2430-2442
Sex, drugs and pain control

A study finds that pain hypersensitivity in male and female mice is differentially dependent on microglia and T cells, and describes a sex-specific response to microglia-targeted pain treatments. This sex difference will be important to consider when developing treatments for pain and other neurological disorders involving microglia and immune cells.

Victoria E Brings
Mark J Zylka
News & Views28 Jul 2015
Nature Neuroscience

Volume: 18, P: 1059-1060
Towards complete and error-free genome assemblies of all vertebrate species

The Vertebrate Genome Project has used an optimized pipeline to generate high-quality genome assemblies for sixteen species (representing all major vertebrate classes), which have led to new biological insights.

Arang Rhie
Shane A. McCarthy
Erich D. Jarvis
ResearchOpen Access28 Apr 2021
Nature

Volume: 592, P: 737-746
AAV-dCas9 vector unsilences paternal Ube3a in neurons by impeding Ube3a-ATS transcription

Snord115-targeted AAV-dCas9 can dose dependently disrupt Ube3a-ATS in the absence of DNA double-strand breaks or a chromatin repression domain, highlighting utility of dCas9 for transcriptional collision-based applications.

Justin M. Wolter
Lucas M. James
Mark J. Zylka
ResearchOpen Access02 Sept 2025
Communications Biology

Volume: 8, P: 1-14
Strobilurin fungicides in house dust: is wallboard a source?

Ellen M. Cooper
Rosie Rushing
Heather M. Stapleton
Research21 Oct 2019
Journal of Exposure Science & Environmental Epidemiology

Volume: 30, P: 247-252
Photochemical activation of TRPA1 channels in neurons and animals

Optovin is a small molecule that renders zebrafish embryos responsive to light through generation of singlet oxygen and activation of the TrpA1b channel, providing a new tool for optogenetics.

David Kokel
Chung Yan J Cheung
Randall T Peterson
Research10 Feb 2013
Nature Chemical Biology

Volume: 9, P: 257-263
Author Correction: scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy

Jennifer Karin Ocasio
Benjamin Babcock
Timothy R. Gershon
Amendments and CorrectionsOpen Access26 May 2022
Nature Communications

Volume: 13, P: 1
Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons

Cancer drugs that can potentially treat Angelman syndrome are identified.

Hsien-Sung Huang
John A. Allen
Benjamin D. Philpot
Research21 Dec 2011
Nature

Volume: 481, P: 185-189
Needling adenosine receptors for pain relief

Acupuncture entails stimulating discrete points on the body with needles to alleviate pain. A study in this issue finds that local activation of adenosine A₁ receptors in mice contributes to the anti-nociceptive effects of acupuncture.

Mark J Zylka
News & Views01 Jul 2010
Nature Neuroscience

Volume: 13, P: 783-784
High-throughput screening and classification of chemicals and their effects on neuronal gene expression using RASL-seq

Jeremy M. Simon
Smita R. Paranjape
Mark J. Zylka
ResearchOpen Access14 Mar 2019
Scientific Reports

Volume: 9, P: 1-9
Developmental pyrethroid exposure and age influence phenotypes in a Chd8 haploinsufficient autism mouse model

Jessica A. Jiménez
Jeremy M. Simon
Mark J. Zylka
ResearchOpen Access01 Apr 2022
Scientific Reports

Volume: 12, P: 1-15

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Zylka et al. reply

Topoisomerases facilitate transcription of long genes linked to autism

Compact Calm1 promoter enables AAV mediated neuron-targeted expression in human iPSC-derived brain organoids

Emerging Roles for Ectonucleotidases in Pain-Sensing Neurons

Cas9 gene therapy for Angelman syndrome traps Ube3a-ATS long non-coding RNA

Multi-targeting zinc finger nuclease vector unsilences paternal UBE3A in a mouse model of Angelman syndrome

Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch

Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration

Single-cell transcriptomic analysis of mouse neocortical development

Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration

scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy

Stimulating Wnt signaling reveals context-dependent genetic effects on gene regulation in primary human neural progenitors

Sex, drugs and pain control

Towards complete and error-free genome assemblies of all vertebrate species

AAV-dCas9 vector unsilences paternal Ube3a in neurons by impeding Ube3a-ATS transcription

Strobilurin fungicides in house dust: is wallboard a source?

Photochemical activation of TRPA1 channels in neurons and animals

Author Correction: scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy

Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons

Needling adenosine receptors for pain relief

High-throughput screening and classification of chemicals and their effects on neuronal gene expression using RASL-seq

Developmental pyrethroid exposure and age influence phenotypes in a Chd8 haploinsufficient autism mouse model

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