Nature Search

G₀ is a major growth cone protein subject to regulation by GAP-43

Stephen M. Strittmatter
Dario Valenzuela
Mark C. Fishman
Research26 Apr 1990
Nature

Volume: 344, P: 836-841
Complete sequencing of ape genomes

Complete sequences of chromosomes telomere-to-telomere from chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan and siamang provide a comprehensive and valuable resource for future evolutionary comparisons.

DongAhn Yoo
Arang Rhie
Evan E. Eichler
ResearchOpen Access09 Apr 2025
Nature

Volume: 641, P: 401-418
Vascular system defects and neuronal apoptosis in mice lacking Ras GTPase-activating protein

Mark Henkemeyer
Derrick J. Rossi
Tony Pawson
Research26 Oct 1995
Nature

Volume: 377, P: 695-701
PDGF induction of tyrosine phosphorylation of GTPase activating protein

Christopher J. Molloy
Donald P. Bottaro
Stuart A. Aaronson
Research07 Dec 1989
Nature

Volume: 342, P: 711-714
Whole-brain annotation and multi-connectome cell typing of Drosophila

A consensus cell type atlas for the fly brain provides both an intellectual framework and open-source toolchains for brain-scale comparative connectomics.

Philipp Schlegel
Yijie Yin
Gregory S. X. E. Jefferis
ResearchOpen Access02 Oct 2024
Nature

Volume: 634, P: 139-152
The challenge of industrializing proteomics

Mark P. Molloy
Correspondence01 Jun 2003
Nature Biotechnology

Volume: 21, P: 597
Consolidation of the cancer genome into domains of repressive chromatin by long-range epigenetic silencing (LRES) reduces transcriptional plasticity

A prostate cancer epigenome map reveals that genes are suppressed in clusters through long-range epigenetic silencing (LRES). Regions of LRES contain known tumour suppressors and miRNAs, and may expand to neighbouring genes during tumour progression.

Marcel W. Coolen
Clare Stirzaker
Susan J. Clark
Research21 Feb 2010
Nature Cell Biology

Volume: 12, P: 235-246
Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria

Severe sepsis has a high mortality rate. Here, the authors provide genomic, transcriptomic, proteomic and metabolomic data across four sepsis-causing pathogens and identify a signature of global increase in fatty acid and lipid biosynthesis as well as cholesterol acquisition.

Andre Mu
William P. Klare
Mark J. Walker
ResearchOpen Access18 Mar 2023
Nature Communications

Volume: 14, P: 1-21
Reconsidering the duty to warn genetically at-risk relatives

Mark A Rothstein
Reviews01 Feb 2018
Genetics in Medicine

Volume: 20, P: 285-290
GDF8 and activin A blockade protects against GLP-1–induced muscle loss while enhancing fat loss in obese male mice and non-human primates

Myostatin and activin A are the two primary negative regulators of muscle mass. Blocking these circulating ligands during GLP-1 therapy induces improved body composition through preservation of lean mass and enhanced fat mass loss in obese primates.

Jason W. Mastaitis
Daniel Gomez
Mark W. Sleeman
ResearchOpen Access13 May 2025
Nature Communications

Volume: 16, P: 1-8
GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture

Genome-wide association meta-analyses identify 26 risk loci for epilepsy, including 19 loci specific to genetic generalized epilepsy. Prioritized candidate genes implicate synaptic processes and overlap with targets of antiseizure medications.

Remi Stevelink
Ciarán Campbell
Quratulain Zulfiqar Ali
ResearchOpen Access31 Aug 2023
Nature Genetics

Volume: 55, P: 1471-1482
Neuronal wiring diagram of an adult brain

FlyWire presents a neuronal wiring diagram of the whole fly brain with annotations for cell types, classes, nerves, hemilineages and predicted neurotransmitters, with data products and an open ecosystem to facilitate exploration and browsing.

Sven Dorkenwald
Arie Matsliah
Meet Zandawala
ResearchOpen Access02 Oct 2024
Nature

Volume: 634, P: 124-138
Neonatal neurocritical care considerations for prenatally identified neurological disorders

Dawn Gano
James P. Boardman
Courtney J. Wusthoff
ReviewsOpen Access07 Jan 2026
Pediatric Research

P: 1-11
Interaction between the nasal microbiota and S. pneumoniae in the context of live-attenuated influenza vaccine

Using a Streptococcus pneumoniae human challenge model, the authors here show that baseline nasal microbiota profiles are associated with pneumococcal acquisition and density, independent of live-attenuated influenza vaccine (LAIV) administration, and with mucosal cytokine responses to LAIV.

Wouter A. A. de Steenhuijsen Piters
Simon P. Jochems
Debby Bogaert
ResearchOpen Access05 Jul 2019
Nature Communications

Volume: 10, P: 1-9
CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia

Ian Blair and colleagues use genome-wide linkage analysis and whole exome sequencing to identify mutations in the CCNF gene in large cohorts of amyotrophic lateral sclerosis and frontotemporal dementia patients. In addition to validating the mutations in international cohorts, the authors also show that mutant CCNFgene product affects ubiquitination and protein degradation in cultured cells.

Kelly L. Williams
Simon Topp
Ian P. Blair
ResearchOpen Access15 Apr 2016
Nature Communications

Volume: 7, P: 1-8
Structural basis for the killing of human beta cells by CD8⁺ T cells in type 1 diabetes

Much is known about crystal structures of MHC class II–autoreactive TCRs. Sewell and colleagues provide the structure of an MHC class I–autoreactive TCR and provide insight into the molecular basis of its diabetogenicity.

Anna M Bulek
David K Cole
Andrew K Sewell
Research15 Jan 2012
Nature Immunology

Volume: 13, P: 283-289
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) is an anti-inflammatory drug proposed as a treatment for COVID19. Here the results are reported from a randomised trial testing DMF treatment in 713 patients hospitalised with COVID-19. DMF was not associated with any improvement in day 5 outcomes.

Peter Sandercock
Janet Darbyshire
Martin J. Landray
ResearchOpen Access31 Jan 2024
Nature Communications

Volume: 15, P: 1-13
Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies

Epilepsies are common brain disorders and are classified based on clinical phenotyping, imaging and genetics. Here, the authors perform genome-wide association studies for 3 broad and 7 subtypes of epilepsy and identify 16 loci - 11 novel - that are further annotated by eQTL and partitioned heritability analyses.

Bassel Abou-Khalil
Pauls Auce
Fritz Zimprich
ResearchOpen Access10 Dec 2018
Nature Communications

Volume: 9, P: 1-15
Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry

SWATH-mass spectrometry consists of a data-independent acquisition and a targeted data analysis strategy that aims to maintain the favorable quantitative characteristics on the scale of thousands of proteins. Here, using data generated by eleven groups worldwide, the authors show that SWATH-MS is capable of generating highly reproducible data across different laboratories.

Ben C. Collins
Christie L. Hunter
Ruedi Aebersold
ResearchOpen Access21 Aug 2017
Nature Communications

Volume: 8, P: 1-12
Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints

Mitochondrial complex II is normally composed of four subunits. Here the authors show that bioenergetic stress conditions give rise to a partially assembled variant of complex II, which shifts the anabolic pathways to less energy demanding processes.

Ayenachew Bezawork-Geleta
He Wen
Jiri Neuzil
ResearchOpen Access07 Jun 2018
Nature Communications

Volume: 9, P: 1-17
Short-term effects of sound localization training in virtual reality

Mark A. Steadman
Chungeun Kim
Lorenzo Picinali
ResearchOpen Access04 Dec 2019
Scientific Reports

Volume: 9, P: 1-17
The role of sensory information in the pathophysiology of focal dystonias

Abnormalities in sensory functions, including tactile, proprioceptive and nociceptive processing, are increasingly recognized in patients with focal dystonias. The authors explore the link between sensory system abnormalities and dystonic motor activity in the context of the 'network model' of dystonia.

Antonella Conte
Giovanni Defazio
Alfredo Berardelli
Reviews30 Jan 2019
Nature Reviews Neurology

Volume: 15, P: 224-233
Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disorder characterised by asthma, eosinophilia and vasculitis. Here, the authors describe a genome-wide association study of EGPA that reveals clinical and genetic differences between subgroups stratified by autoantibody status (ANCA).

Paul A Lyons
James E Peters
Kenneth G. C. Smith
ResearchOpen Access12 Nov 2019
Nature Communications

Volume: 10, P: 1-13
The Methylazoxymethanol Acetate (MAM-E17) Rat Model: Molecular and Functional Effects in the Hippocampus

Eva Hradetzky
Thomas M Sanderson
Sabine Bahn
Research28 Sept 2011
Neuropsychopharmacology

Volume: 37, P: 364-377
Pledging intellectual property for COVID-19

Voluntary pledges to make intellectual property broadly available to address urgent public health crises can overcome administrative and legal hurdles faced by more elaborate legal arrangements such as patent pools and achieve greater acceptance than governmental compulsory licensing.

Jorge L. Contreras
Michael Eisen
Frank Tietze
Comments & Opinion05 Oct 2020
Nature Biotechnology

Volume: 38, P: 1146-1149
Ad26/MVA therapeutic vaccination with TLR7 stimulation in SIV-infected rhesus monkeys

A combination of therapeutic vaccination with Ad26/MVA and stimulation of innate immune responses leads to improved virologic control and delayed rebound in SIV-infected macaques following discontinuation of antiretroviral therapy.

Erica N. Borducchi
Crystal Cabral
Dan H. Barouch
Research09 Nov 2016
Nature

Volume: 540, P: 284-287
Characterization of the Disruptions of Prepulse Inhibition and Habituation of Startle Induced by α-Ethyltryptamine

Diana L Martinez
Mark A Geyer
Research01 Mar 1997
Neuropsychopharmacology

Volume: 16, P: 246-255
Therapeutic potential of synthetic microRNA mimics based on the miR-15/107 consensus sequence

Glen Reid
Marissa Williams
Nico van Zandwijk
ResearchOpen Access22 Mar 2025
Cancer Gene Therapy

Volume: 32, P: 486-496
Effects of Acute and Chronic Alprazolam Treatment on Cerebral Blood Flow, Memory, Sedation, and Plasma Catecholamines

Peter Roy-Byre
Joseph Fleishaker
Michael Graham
Research01 Feb 1993
Neuropsychopharmacology

Volume: 8, P: 161-169
Proteomics of thyroid tumours provides new insights into their molecular composition and changes associated with malignancy

Juan Martínez-Aguilar
Roderick Clifton-Bligh
Mark P. Molloy
ResearchOpen Access30 Mar 2016
Scientific Reports

Volume: 6, P: 1-12
Proteomic phenotyping of metastatic melanoma reveals putative signatures of MEK inhibitor response and prognosis

Christoph Krisp
Robert Parker
Mark P. Molloy
ResearchOpen Access17 Aug 2018
British Journal of Cancer

Volume: 119, P: 713-723
Plasma biomarker proteins for detection of human growth hormone administration in athletes

Sock-Hwee Tan
Albert Lee
Alamgir Khan
ResearchOpen Access30 Aug 2017
Scientific Reports

Volume: 7, P: 1-12
Sustained translational repression by eIF2α-P mediates prion neurodegeneration

Accumulation of prion protein during prion replication causes persistent translational repression of global protein synthesis, which is mediated by eIF2α-P and is associated with synaptic failure and neuronal loss in prion-diseased mice; promoting translational recovery in hippocampi of prion-infected mice is neuroprotective.

Julie A. Moreno
Helois Radford
Giovanna R. Mallucci
Research06 May 2012
Nature

Volume: 485, P: 507-511
Inhibition of Aurora B kinase (AURKB) enhances the effectiveness of 5-fluorouracil chemotherapy against colorectal cancer cells

Esha T. Shah
Christopher Molloy
Mark N. Adams
ResearchOpen Access29 Jan 2024
British Journal of Cancer

Volume: 130, P: 1196-1205
Overlapping genes in natural and engineered genomes

The authors review overlapping sequences as fundamental features of prokaryotic, eukaryotic and viral genomes, discussing the diverse topologies and functions of overlapping genes, open reading frames and coding sequences. Moreover, they highlight the potential of harnessing sequence overlaps for synthetic biology approaches.

Bradley W. Wright
Mark P. Molloy
Paul R. Jaschke
Reviews05 Oct 2021
Nature Reviews Genetics

Volume: 23, P: 154-168
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation

David H Gutmann
Allison Loehr
Amanda Cashen
Research04 Aug 1999
Oncogene

Volume: 18, P: 4450-4459
Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy

Kildey et al find that high levels of mitotic regulator CDCA3 correlates with sensitivity to platinum agents in non-small cell lung cancer patients and cell lines. They show that interfering with CDCA3 degradation through CK2 inhibition enhances CDCA3 levels and increases sensitivity to platinum agents suggesting a therapeutic route.

Katrina Kildey
Neha S. Gandhi
Mark N. Adams
ResearchOpen Access28 May 2021
Communications Biology

Volume: 4, P: 1-12
Correction: Neonatal sepsis definitions from randomised clinical trials

Rían Hayes
Jack Hartnett
Eleanor J. Molloy
Amendments and CorrectionsOpen Access29 Jul 2024
Pediatric Research

Volume: 96, P: 1882
Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes

Mehdi Mirzaei
Veer B. Gupta
Vivek K. Gupta
ResearchOpen Access04 Oct 2017
Scientific Reports

Volume: 7, P: 1-16
Characterisation of the immune compounds in koala milk using a combined transcriptomic and proteomic approach

Katrina M. Morris
Denis O’Meally
Katherine Belov
ResearchOpen Access07 Oct 2016
Scientific Reports

Volume: 6, P: 1-14
Correction: Neonatal sepsis: need for consensus definition, collaboration and core outcomes

Eleanor J. Molloy
James L. Wynn
Irwin K. M. Reiss
Amendments and Corrections29 Oct 2020
Pediatric Research

Volume: 90, P: 232
Neonatal sepsis: need for consensus definition, collaboration and core outcomes

Eleanor J. Molloy
James L. Wynn
Irwin K. M. Reiss
Editorial19 Mar 2020
Pediatric Research

Volume: 88, P: 2-4
Asperger’s syndrome – about time to rename it?

Cynthia Bearer
Steven H. Abman
John Zupancic
Editorial13 Nov 2023
Pediatric Research

Volume: 95, P: 582-584
Neonatal sepsis definitions from randomised clinical trials

Rían Hayes
Jack Hartnett
Eleanor J. Molloy
ReviewsOpen Access06 Nov 2021
Pediatric Research

Volume: 93, P: 1141-1148
Neonatal sepsis: a systematic review of core outcomes from randomised clinical trials

Cían J. Henry
Gergana Semova
Eleanor J. Molloy
ReviewsOpen Access07 Jan 2022
Pediatric Research

Volume: 91, P: 735-742
Challenges in developing a consensus definition of neonatal sepsis

Matthew McGovern
Eric Giannoni
Eleanor J. Molloy
Reviews03 Mar 2020
Pediatric Research

Volume: 88, P: 14-26
Toward the elimination of bias in Pediatric Research

Cynthia Bearer
Carlo Agostoni
Eleanor Molloy
Editorial18 Sept 2019
Pediatric Research

Volume: 86, P: 680-681
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22
The future of pediatric research: European perspective

Eleanor J. Molloy
Neena Modi
Mark Turner
Comments & Opinion04 Nov 2016
Pediatric Research

Volume: 81, P: 138-139

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