Nature Search

Induction of yeast Ty element transcription by ultraviolet light

Mark Rolfe
Ad Spanos
Geoffrey Banks
Research23 Jan 1986
Nature

Volume: 319, P: 339-340
Antisense targeting of E6AP elevates p53 in HPV-infected cells but not in normal cells

Peggy Beer-Romero
Susan Glass
Mark Rolfe
Research06 Feb 1997
Oncogene

Volume: 14, P: 595-602
The human UNP locus at 3p21.31 encodes two tissue-selective, cytoplasmic isoforms with deubiquitinating activity that have reduced expression in small cell lung carcinoma cell lines

Amy Frederick
Mark Rolfe
M Isabel Chiu
Research23 Jan 1998
Oncogene

Volume: 16, P: 153-165
Correction: Corrigendum: Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

Luca A Lotta
Pawan Gulati
Robert A Scott
Amendments and Corrections31 Jan 2017
Nature Genetics

Volume: 49, P: 317
The Effect of Postnatal Age on the Adherence of Enterohemorrhagic Escherichia coli to Rabbit Intestinal Cells

Shai Ashkenazi
Lauri May
Thomas G Cleary
Research01 Jan 1991
Pediatric Research

Volume: 29, P: 14-19
Shotgun sequencing of airborne eDNA achieves rapid assessment of whole biomes, population genetics and genomic variation

The authors report shotgun sequences from airborne environmental DNA samples, identifying local biodiversity and enabling deeper analysis of specific species and genomic regions of interest.

Orestis Nousias
Mark McCauley
David J. Duffy
ResearchOpen Access03 Jun 2025
Nature Ecology & Evolution

Volume: 9, P: 1043-1060
Crystal structure of the SALL4–pomalidomide–cereblon–DDB1 complex

The structure of the second zinc finger of SALL4 in complex with pomalidomide, cereblon and DDB1 reveals the unique details of SALL4 recruitment, providing insights for rational design of cereblon-binding drugs with reduced teratogenic risk.

Mary E. Matyskiela
Thomas Clayton
Philip P. Chamberlain
Research06 Apr 2020
Nature Structural & Molecular Biology

Volume: 27, P: 319-322
SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate

Thalidomide-induced degradation of the transcription factor SALL4 in a cereblon-dependent manner provides an explanation for the teratogenic effects.

Mary E. Matyskiela
Suzana Couto
Philip P. Chamberlain
Research06 Sept 2018
Nature Chemical Biology

Volume: 14, P: 981-987
Structure–based design and characterization of exocyclic peptidomimetics that inhibit TNFα binding to its receptor

Wataru Takasaki
Yuri Kajino
Mark I. Greene
Research01 Nov 1997
Nature Biotechnology

Volume: 15, P: 1266-1270
Deeper and stronger North Atlantic Gyre during the Last Glacial Maximum

Analysis of benthic foraminiferal δ¹⁸O profiles from sediment cores in two depth transects in the Northwest Atlantic suggests that the subtropical gyre was deeper and stronger during the Last Glacial Maximum compared with today.

Jack H. Wharton
Martin Renoult
David J. R. Thornalley
ResearchOpen Access10 Jul 2024
Nature

Volume: 632, P: 95-100
Spontaneous Variability in Minute Ventilation Oxygen Consumption and Heart Rate of Low Birth Weight Infants

Karl Schulze
Ram Kairam
L S James
Research01 Aug 1981
Pediatric Research

Volume: 15, P: 1111-1116
The International Conference on Hybridisation and Cross-Breeding

WILFRED MARK WEBB
News27 Jul 1899
Nature

Volume: 60, P: 305-307
Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

Luca Lotta, Robert Scott, Stephen O’Rahilly, Claudia Langenberg, David Savage, Nicholas Wareham, Inês Barroso and colleagues identify 53 genomic regions associated with insulin resistance phenotypes. Their findings suggest that limited storage capacity of peripheral adipose tissue is an important etiological component in insulin-resistant cardiometabolic disease and highlight genes and mechanisms underpinning this link.

Luca A Lotta
Pawan Gulati
Robert A Scott
Research14 Nov 2016
Nature Genetics

Volume: 49, P: 17-26
Genetic and pharmacological interrogation of cancer vulnerability using a multiplexed cell line screening platform

Xia et al. report the development and optimization of a high-throughput screening platform to systematically determine cancer cell sensitivity to pharmacological and genetic perturbations, BMS-PRISM, based on PRISM and high-throughput CRISPR/Cas9 loss-of-function screen technologies using cell line barcoding.

Yifeng Xia
Xiaodong Ji
Gang Lu
ResearchOpen Access02 Jul 2021
Communications Biology

Volume: 4, P: 1-7
Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials

Hydroxychloroquine and chloroquine have been investigated as a potential treatment for Covid-19 in several clinical trials. Here the authors report a meta-analysis of published and unpublished trials, and show that treatment with hydroxychloroquine for patients with Covid-19 was associated with increased mortality, and there was no benefit from chloroquine.

Cathrine Axfors
Andreas M. Schmitt
Lars G. Hemkens
ResearchOpen Access15 Apr 2021
Nature Communications

Volume: 12, P: 1-13
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

This study has developed the first small molecule NEDD8-activating enzyme (NAE) inhibitor, which induces cancer cell death and exerts anti-tumour activity in preclinical mouse models. This work establishes NAE as an anti-cancer target and may lead to new anti-cancer therapeutics.

Teresa A. Soucy
Peter G. Smith
Steven P. Langston
Research09 Apr 2009
Nature

Volume: 458, P: 732-736
Inadvertent human genomic bycatch and intentional capture raise beneficial applications and ethical concerns with environmental DNA

The recovery of human genomic data from environmental DNA samples raises ethical questions regarding consent, privacy, surveillance and data ownership, which will need to be grappled with as the environmental DNA field moves forward.

Liam Whitmore
Mark McCauley
David J. Duffy
ResearchOpen Access15 May 2023
Nature Ecology & Evolution

Volume: 7, P: 873-888
Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials

Cathrine Axfors
Andreas M. Schmitt
Lars G. Hemkens
Amendments and CorrectionsOpen Access05 Feb 2024
Nature Communications

Volume: 15, P: 1-2
Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials

Cathrine Axfors
Andreas M. Schmitt
Lars G. Hemkens
Amendments and CorrectionsOpen Access14 May 2021
Nature Communications

Volume: 12, P: 1-2
Drug discovery in the ubiquitin–proteasome system

The ubiquitin–proteasome pathway contains a large number of components that are possible drug targets for cancer and other diseases. Nalepaet al. review evidence linking components of this pathway to human disease and discuss potential strategies for therapeutic intervention.

Grzegorz Nalepa
Mark Rolfe
J. Wade Harper
Reviews01 Jul 2006
Nature Reviews Drug Discovery

Volume: 5, P: 596-613
Ubiquitin and the Biology of the Cell

Mark Rolfe
Books & Arts01 Nov 1998
Nature Medicine

Volume: 4, P: 1326
Making Better Drugs: Decision Gates in Non-Clinical Drug Development

J. Fred Pritchard
Malle Jurima-Romet
Mitchell N. Cayen
Reviews01 Jul 2003
Nature Reviews Drug Discovery

Volume: 2, P: 542-553
Analysis of Resident and Transformant Plasmids in Bacillus Megaterium

Mark K. Kieselburg
Michael Weickert
Patricia S. Vary
Research01 Mar 1984
Bio/Technology

Volume: 2, P: 254-259
USP7 small-molecule inhibitors interfere with ubiquitin binding

The development of selective ubiquitin-specific protease-7 (USP7) inhibitors GNE-6640 and GNE-6776, which induce tumour cell death and reveal differential kinetics of Lys-48 and Lys-63-linked ubiquitin chain depolymerization by USP7.

Lorna Kategaya
Paola Di Lello
Ingrid E. Wertz
Research18 Oct 2017
Nature

Volume: 550, P: 534-538

Search

Induction of yeast Ty element transcription by ultraviolet light

Antisense targeting of E6AP elevates p53 in HPV-infected cells but not in normal cells

The human UNP locus at 3p21.31 encodes two tissue-selective, cytoplasmic isoforms with deubiquitinating activity that have reduced expression in small cell lung carcinoma cell lines

Correction: Corrigendum: Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

The Effect of Postnatal Age on the Adherence of Enterohemorrhagic Escherichia coli to Rabbit Intestinal Cells

Shotgun sequencing of airborne eDNA achieves rapid assessment of whole biomes, population genetics and genomic variation

Crystal structure of the SALL4–pomalidomide–cereblon–DDB1 complex

SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate

Structure–based design and characterization of exocyclic peptidomimetics that inhibit TNFα binding to its receptor

Deeper and stronger North Atlantic Gyre during the Last Glacial Maximum

Spontaneous Variability in Minute Ventilation Oxygen Consumption and Heart Rate of Low Birth Weight Infants

The International Conference on Hybridisation and Cross-Breeding

Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

Genetic and pharmacological interrogation of cancer vulnerability using a multiplexed cell line screening platform

Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

Inadvertent human genomic bycatch and intentional capture raise beneficial applications and ethical concerns with environmental DNA

Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials

Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials

Drug discovery in the ubiquitin–proteasome system

Ubiquitin and the Biology of the Cell

Making Better Drugs: Decision Gates in Non-Clinical Drug Development

Analysis of Resident and Transformant Plasmids in Bacillus Megaterium

USP7 small-molecule inhibitors interfere with ubiquitin binding

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