Noncoding RNAs have been implicated in targeting the repressive polycomb complex PRC2 to specific genomic sites. In vivo cross-linking studies now reveal a number of intronic RNA sequences capable of binding the EZH2 subunit of PRC2 in human cancer cells and downregulating transcription of the SMYD3 histone methyltransferase gene, among others. Overexpression of an EZH2-interacting RNA was found to counteract tumorigenicity.
- Sònia Guil
- Marta Soler
- Manel Esteller
