Nucleic acid-based therapy and diagnosis require improved methods for synthesising stable oligonucleotide conjugates. Here, the authors introduce a method for direct functionalization of various amino-modified oligonucleotides (AONs), enabling dual-functionalization of AONs and the synthesis of fluorescent peptide-oligonucleotide conjugates.
- Jan H. Meffert
- Mónica Lopes
- Annemieke Madder
