Nature Search

Erratum: Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis

Masaru Ishii
Jackson G. Egen
Ronald N. Germain
Amendments and Corrections17 Jun 2010
Nature

Volume: 465, P: 966
Concomitant regulation of T-cell activation and homeostasis

Zvi Grossman
Booki Min
William E. Paul
Reviews01 May 2004
Nature Reviews Immunology

Volume: 4, P: 387-395
Granzyme K⁺ CD8 T cells slow tauopathy progression by targeting microglia

McGavern and colleagues identified a CD8⁺ T cell population that expresses GZMK in ʽtau-richʼ brains, where it may play a protective role against neurodegeneration.

Hannah D. Mason
Yvonne L. Latour
Dorian B. McGavern
Research24 Jun 2025
Nature Immunology

Volume: 26, P: 1152-1167
Computational modeling of cellular signaling processes embedded into dynamic spatial contexts

Molecular processes in cells are not spatially homogenous. Reported here is an approach, implemented in the Simmune toolset, for modeling cellular processes within their dynamic spatial context.

Bastian R Angermann
Frederick Klauschen
Martin Meier-Schellersheim
Research29 Jan 2012
Nature Methods

Volume: 9, P: 283-289
Structural mechanism of anti-MHC-I antibody blocking of inhibitory NK cell receptors in tumor immunity

The B1.23.2 antibody binds HLA-B*44:05 at a site that overlaps the killer Ig-like receptor binding site. It blocks inhibitory receptor interactions, leads to NK cell activation and suppresses tumor growth in a humanized mouse model.

Jiansheng Jiang
Abir K. Panda
David H. Margulies
ResearchOpen Access02 Feb 2026
Communications Biology

Volume: 9, P: 1-16
Inflammation-induced interstitial migration of effector CD4⁺ T cells is dependent on integrin α_V

Inflammation induces changes in the extracellular matrix density and composition. Fowell and colleagues show that CD4⁺ effector T cells use integrin α_V for interstitial migration on fibronectin in inflamed tissues.

Michael G Overstreet
Alison Gaylo
Deborah J Fowell
Research11 Aug 2013
Nature Immunology

Volume: 14, P: 949-958
Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines

The creation and application of engineered constructs specific for one of two IL-4 coreceptors explain how immune signaling is limited by coreceptor concentration and establish specific roles for type II receptor–specific signaling in dendritic cell differentiation.

Ilkka S Junttila
Remi J Creusot
K Christopher Garcia
Research28 Oct 2012
Nature Chemical Biology

Volume: 8, P: 990-998
CD4⁺ T-cell depletion in HIV infection: Are we closer to understanding the cause?

Is CD4⁺ cell depletion due to rapid elimination by HIV and failure of the immune system to replace these cells at the required rate? Increasing evidence suggests that this is not the case, and that infection-induced immune activation drives both viral replication and CD4⁺ cell depletion.

Zvi Grossman
Martin Meier-Schellersheim
William E. Paul
Comments & Opinion01 Apr 2002
Nature Medicine

Volume: 8, P: 319-323
Computational reconstruction of cell and tissue surfaces for modeling and data analysis

Frederick Klauschen
Hai Qi
Martin Meier-Schellersheim
Protocols11 Jun 2009
Nature Protocols

Volume: 4, P: 1006-1012
TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

Irena Štefanová
Bernhard Hemmer
Ronald N. Germain
Research10 Feb 2003
Nature Immunology

Volume: 4, P: 248-254
A negative-feedback loop maintains optimal chemokine concentrations for directional cell migration

Lau et al. quantify endogenous concentrations of the chemokine Cxcl12 and its binding affinity for its cognate receptor Cxcr4 in zebrafish embryos, uncovering a negative-feedback loop governing directional cell migration in vivo.

Stephanie Lau
Anna Feitzinger
Holger Knaut
Research10 Feb 2020
Nature Cell Biology

Volume: 22, P: 266-273
Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis

Osteoclasts resorb bone and their precursor cells express sphingosine-1-phosphate (S1P) receptors. Too much S1P, and too many osteoclast precursors move into the blood; too little S1P results in increased attachment to bone and osteoporosis. Furthermore, S1P receptor stimulation in live mice diminishes bone loss in a mouse model of postmenopausal osteoporosis.

Masaru Ishii
Jackson G. Egen
Ronald N. Germain
Research08 Feb 2009
Nature

Volume: 458, P: 524-528
Pathogenesis of HIV infection: what the virus spares is as important as what it destroys

Zvi Grossman
Martin Meier-Schellersheim
Louis J Picker
Reviews06 Mar 2006
Nature Medicine

Volume: 12, P: 289-295
SARS-CoV-2 antibodies recognize 23 distinct epitopic sites on the receptor binding domain

Systematic investigation and a clustering method to analyze 340 antibody and 83 nanobody structures reveal 23 distinct epitopic sites on the SARS-CoV-2 spike protein’s RBD and the frequencies of amino acid usage in the CDR paratopes.

Jiansheng Jiang
Christopher T. Boughter
David H. Margulies
ResearchOpen Access19 Sept 2023
Communications Biology

Volume: 6, P: 1-15
Quantifying cellular interaction dynamics in 3D fluorescence microscopy data

Frederick Klauschen
Masaru Ishii
Martin Meier-Schellersheim
Protocols20 Aug 2009
Nature Protocols

Volume: 4, P: 1305-1311
Absolute protein quantitation of the mouse macrophage Toll-like receptor and chemotaxis pathways

Nathan P. Manes
Jessica M. Calzola
Aleksandra Nita-Lazar
ResearchOpen Access12 Aug 2022
Scientific Data

Volume: 9, P: 1-13

Search

Filter By:

Search

Quick links