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The authors introduce a new spectroscopic technique for studying Higgs modes in superconductors and apply it to a cuprate superconductor. The method involves a soft quench of the Mexican-Hat potential, populating Higgs modes of different symmetries, which are then probed by non equilibrium anti-Stokes Raman scattering.

The most up-to-date combination of results on the properties of the Higgs boson is reported, which indicate that its properties are consistent with the standard model predictions, within the precision achieved to date.

Ten years after the discovery of the Higgs boson, the ATLAS  experiment at CERN probes its kinematic properties with a significantly larger dataset from 2015–2018 and provides further insights on its interaction with other known particles.

The Higgs mechanism is best known for generating mass for subatomic particles. Less well-known is that the idea originated in the study of superconductivity, and can be tested in the laboratory.

The CMS Collaboration reports evidence for off-shell Higgs boson contributions in the production of Z boson pairs, and measures the width of the Higgs boson, which is inversely related to its lifetime.

Quantum spin ice is a magnetic state of matter which can play host to monopole excitations. Using polarized neutron scattering, Changet al. show that the quantum spin ice material ytterbium titanate undergoes a Higgs transition of emergent magnetic monopoles from a Coulomb liquid to a ferromagnetic phase.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

The ATLAS Collaboration reports the observation of the electroweak production of two jets and a Z-boson pair. This process is related to vector-boson scattering and allows the nature of electroweak symmetry breaking to be probed.

At ultrafast time scales, for example, through light-matter interactions, exotic phases in quantum systems can be realised but identifying and characterising these phases from other excitations is complex. Here, the authors theoretically demonstrate how to identify the experimental signatures of a non-equilibrium superconducting state using multi-dimensional coherent spectroscopy in the terahertz regime.

S. Gassner et al. propose using light pulses to drive a centrosymmetric s-wave superconductor with strong spin-orbit coupling into a metastable triplet p-wave superconductor with non-trivial topology. The two superconducting orders must be closely competing in equilibrium and the light pulse must break a generalized, dynamic form of inversion symmetry.

The ATLAS experiment at the Large Hadron Collider reports a search for charged-lepton-flavour violation in decays of Z bosons into a τ lepton and an electron or muon of opposite charge.

Cuprate superconductors are known for their intertwined interactions and coexistence of competing orders. Here, the authors observe a Fano resonance in the nonlinear THz response of La_2-xSr_xCuO₄, which may arise from a coupling between superconducting and charge-density-wave amplitude fluctuations.

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb⁻¹.

The Large Hadron Collider beauty collaboration reports a test of lepton flavour universality in decays of bottom mesons into strange mesons and a charged lepton pair, finding evidence of a violation of this principle postulated in the standard model.

The LHCb experiment at CERN has observed significant asymmetries between the decay rates of the beauty baryon and its CP-conjugated antibaryon, thus demonstrating CP violation in baryon decays.

Combined analysis of proton-proton collision data from the Large Hadron Collider at CERN by the CMS and LHCb collaborations leads to the observation of the extremely rare decay of the strange B meson into muons; the result is compatible with the standard model of particle physics, and does not show any signs of new physics, such as supersymmetry.

Chikungunya virus is a mosquito transmitted untreatable emergent pathogen that causes joint pain and fever. Here the authors perform a host genome-wide loss-of-function screen to identify targets for chikungunya antiviral drugs and validate hits using a mouse model of chikungunya infection.

Inversion of the mouse α-globin super-enhancer reverses expression and interaction profiles of flanking genes. Contrary to the orientation-independent paradigm of enhancers, this super-enhancer acts in an orientation-dependent manner.

Here the authors identify that C16orf72 regulates BRCA1/Senataxin to promote replication fork recovery. These proteins act together in a pathway parallel to PARP1 to suppress R-loop accumulation in response to replication stress and confer resistance to PARP inhibitors.

Measurement of the asymmetry in the parity-violating scattering of polarized electrons on protons gives the weak charge of the proton as 0.0719 ± 0.0045, in agreement with the standard model.

Grant Stewart, Andrew Jackson, Christopher Mathew, Fowzan Alkuraya and colleagues identify a novel replication fork protein, DONSON, which is important for maintaining genome stability. Mutations in DONSON cause microcephalic dwarfism and lead to stalled replication forks and DNA damage.

The non-coding RNA RNU4-2, which is highly expressed in the developing human brain, is identified as a syndromic neurodevelopmental disorder gene, and, using RNA sequencing, 5′ splice-site use is shown to be systematically disrupted in individuals with RNU4-2 variants.

The development of IgG and albumin-based therapeutics with increased half-lives needs more efficient screening procedures. Here the authors report a human endothelial cell-based recycling assay enabling screening of IgG and albumin variants without chemical labelling and prior to animal testing.

Quantum simulations of the fundamental particles and forces of nature have a central role in understanding key static and dynamic quantum properties of matter. Motivations, techniques and future challenges for simulations of quantum fields are discussed, highlighting examples of early progress towards the dynamics of high-density, non-equilibrium systems of quarks, gluons and neutrinos.

Mutations in the ADD domain of ATRX protein lead to severe mental retardation. Now the importance of this domain for targeting ATRX to heterochromatin is examined; ADD simultaneously recognizes unmethylated lysine 4 and trimethylated lysine 9 of histone H3, making it a combinatorial reader. This readout is enhanced by interaction with HP-1, forming a tripartite network that may bridge adjacent nucleosomes.

Martin Pollak and colleagues show that missense mutations in the diaphanous inhibitory domain of INF2 cause focal segmental glomerular sclerosis. INF2 encodes a member of the formin family of actin-regulating proteins, highlighting an important role for actin dynamics in podocyte function.

The SMC5/6 complex is critical for genome stability. Here, the authors identify mutations in SLF2 and SMC5 as cause of Atelís Syndrome characterized by microcephaly, short stature, anemia, segmented chromosomes and mosaic variegated hyperploidy.

Spectroscopic techniques can probe atomic and molecular gases with exquisite precision. This Review discusses the wide array of methods that have been developed and applied to study many-body physics in ultracold gases.

Mutagenic lesions such as those that give rise to cancer frequently segregate—unrepaired—during cell division, resulting in phasing of multiple alleles across generations of daughter cells and consequent tumour heterogeneity.

Andrew Jackson, Grant Stewart, Bernd Wollnik and colleagues identify TRAIP mutations in three patients with primordial dwarfism. They show that TRAIP is involved in DNA damage response during genome replication and is necessary for efficient cell cycle progression.

Gilean McVean and colleagues report the results of a large-scale clinical genome sequencing project spanning a broad spectrum of disorders. They identify factors influencing successful genetic diagnosis and highlight the challenges of interpreting findings for genetically heterogeneous disorders.

A spectroscopic approach based on the Rabi resonance method is used to probe the quantum states of ultracold neutrons—and thus their interaction with the gravitational potential of the Earth.

Whole-genome sequence data for 108 individuals representing 28 language groups across Australia and five language groups for Papua New Guinea suggests that Aboriginal Australians and Papuans diverged from Eurasian populations approximately 60–100 thousand years ago, following a single out-of-Africa dispersal and subsequent admixture with archaic populations.

Spectroscopic study of the low-energy excitations in magnetite Fe₃O₄ shows the signatures of its charge-ordered structure involved in the metal–insulator transition, whose building blocks are the three-site small polarons, termed trimerons.

PARP1 has a well characterised role in DNA break repair and base excision repair, whereas the role of PARP2 is less well understood. Here, the authors show a requirement for PARP2 in stabilising replication forks that encounter base excision repair intermediates.