Major depressive disorder (MDD) exhibits sex-specific differences in onset, symptoms and treatment response, yet biomarkers for guiding sex-specific interventions remain unidentified. Here the authors propose the use of resting-state functional magnetic resonance imaging to uncover sex-based neural differences in MDD, advocating for larger studies to enhance diagnostic tools and personalized treatments.
- Malvika Sridhar
- Wiebke Struckmann
- Nolan R. Williams
