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Showing 1–3 of 3 results
Advanced filters: Author: Marvin T. Nieman Clear advanced filters

  • While neutrophils are the first line of defence against infections and inflammation, their unrestricted recruitment and constant activation might result in prolonged inflammation and sharpening of specific pathological conditions. Here the authors develop a strategy to specifically target activated, pro-inflammatory neutrophils and neutrophil–platelet complexes to deliver therapeutics in the context of a murine model of venous thrombosis.

    • Michelle A. Cruz
    • Dillon Bohinc
    • Evi X. Stavrou
    Research
    Nature Nanotechnology
    Volume: 17, P: 1004-1014

  • Preserving hemostasis while preventing pathological thrombosis has been a central goal in drug development. A new way to restore hemostasis is suggested by the finding that glycoprotein V is cleaved by thrombin on activated platelets, negatively regulating clotting at sites of vascular injury.

    • Elizabeth A. Knauss
    • Marvin T. Nieman
    News & Views
    Nature Cardiovascular Research
    Volume: 2, P: 335-336

  • Serotonin receptor (5-HT3AR), a pentameric ligand-gated ion channel, regulates numerous gastrointestinal functions. Here the authors provide a cryo-electron microscopic structure from the full-length 5-HT3AR in the apo-state which corresponds to a resting conformation of the channel.

    • Sandip Basak
    • Yvonne Gicheru
    • Sudha Chakrapani
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10