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Showing 1–3 of 3 results
Advanced filters: Author: MaryAnne A. Achieng Clear advanced filters

  • A versatile, human iPSC-derived nephron engineering platform that permits scrutiny of axial patterning mechanisms is critical for identifying the origins of human kidney disease. Here they describe a system in which synchronized human nephron structures are generated from pluripotent stem cells, enabling manipulation of axial segmentation.

    • MaryAnne A. Achieng
    • Jack Schnell
    • Nils O. Lindström
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Our understanding of nephrogenesis has been aided by studies that have compared features of human and mouse nephrogenesis, and by technological advances in single-cell omics and high-resolution imaging techniques. This Review describes current understanding of nephron patterning, focusing on the processes by which nephron progenitors are recruited into the developing nephron.

    • Jack Schnell
    • MaryAnne Achieng
    • Nils Olof Lindström
    Reviews
    Nature Reviews Nephrology
    Volume: 18, P: 628-642