Nature Search

FR177391, A New Anti-hyperlipidemic Agent from Serratia

Masamichi Inami
Ikuo Kawamura
Seitaro Mutoh
Research01 Oct 2005
The Journal of Antibiotics

Volume: 58, P: 640-647
Heterogeneous photocatalytic oxidation of aromatic compounds on TiO₂

Masamichi Fujihira
Yoshiharu Satoh
Tetsuo Osa
Research17 Sept 1981
Nature

Volume: 293, P: 206-208
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Erratum: Rational design of a high-affinity, fast, red calcium indicator R-CaMP2

Masatoshi Inoue
Atsuya Takeuchi
Haruhiko Bito
Amendments and Corrections28 Aug 2015
Nature Methods

Volume: 12, P: 893
AID mutant analyses indicate requirement for class-switch-specific cofactors

Van-Thanh Ta
Hitoshi Nagaoka
Tasuku Honjo
Research10 Aug 2003
Nature Immunology

Volume: 4, P: 843-848
Separate domains of AID are required for somatic hypermutation and class-switch recombination

Reiko Shinkura
Satomi Ito
Tasuku Honjo
Research13 Jun 2004
Nature Immunology

Volume: 5, P: 707-712
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Low-voltage-area ablation for persistent atrial fibrillation: a randomized controlled trial

In view of previous work suggesting that low-voltage areas may promote atrial fibrillation, a multicenter, randomized controlled trial tested the hypothesis that ablation of low-voltage areas in addition to pulmonary vein isolation might reduce the recurrence of atrial arrhythmic events, but found no significant benefit to the combined procedure.

Masaharu Masuda
Akihiro Sunaga
Takuya Ohashi
ResearchOpen Access30 Apr 2025
Nature Medicine

Volume: 31, P: 1661-1667
Spatiotemporal transcriptome analysis reveals critical roles for mechano-sensing genes at the border zone in remodeling after myocardial infarction

Komuro et al. performed an integrative analysis of single-nucleus RNA sequencing and spatial transcriptome analysis of the injured heart to map cellular and molecular changes across topographical domains relative to the site of injury, and they identify that mechano-sensing genes at the border zone act as adaptive regulators of left ventricular remodeling.

Shintaro Yamada
Toshiyuki Ko
Issei Komuro
ResearchOpen Access17 Nov 2022
Nature Cardiovascular Research

Volume: 1, P: 1072-1083
Efficacy of combined transbronchial lung cryobiopsy and conventional forceps biopsy for lung malignancies: a prospective cohort study

Kohei Kinoshita
Kei Morikawa
Masamichi Mineshita
ResearchOpen Access01 Feb 2023
Scientific Reports

Volume: 13, P: 1-8
Acceleration Mechanism of Nucleation of Polymers by Nano-sizing of Nucleating Agent

Tsuyoshi Urushihara
Kiyoka Okada
Masamichi Hikosaka
Research07 Dec 2006
Polymer Journal

Volume: 39, P: 55-64
Microscopically-Viewed Structural Change of Polyethylene during Isothermal Crystallization from the Melt I. Time-Resolved FT-IR Spectral Measurements

Kohji Tashiro
Sono Sasaki
Masamichi Kobayashi
Research01 Jun 1998
Polymer Journal

Volume: 30, P: 485-491
In situ class switching and differentiation to IgA-producing cells in the gut lamina propria

Sidonia Fagarasan
Kazuo Kinoshita
Tasuku Honjo
Research11 Oct 2001
Nature

Volume: 413, P: 639-643
Rational design of a high-affinity, fast, red calcium indicator R-CaMP2

An improved genetically encoded red calcium sensor enables the monitoring of neuronal activity in cell culture and in vivo. R-CaMP2 has fast kinetics and a high affinity to calcium and can follow action potentials up to 40 Hz.

Masatoshi Inoue
Atsuya Takeuchi
Haruhiko Bito
Research24 Nov 2014
Nature Methods

Volume: 12, P: 64-70
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
New reference values for ultrasound fetal biometry in Japanese population and comparison with other studies

Sumito Nagasaki
Keisuke Ishii
Hirokazu Yorioka
ResearchOpen Access20 Aug 2025
Scientific Reports

Volume: 15, P: 1-12
Dzip3 regulates developmental genes in mouse embryonic stem cells by reorganizing 3D chromatin conformation

Daishi Inoue
Hitoshi Aihara
Takashi Ito
ResearchOpen Access16 Nov 2015
Scientific Reports

Volume: 5, P: 1-11
A prospective cohort study of periostin as a serum biomarker in patients with idiopathic pulmonary fibrosis treated with nintedanib

Masaki Okamoto
Kiminori Fujimoto
Tomoaki Hoshino
ResearchOpen Access27 Dec 2023
Scientific Reports

Volume: 13, P: 1-15
Diffuse pulmonary ossification and its association with cicatricial organising pneumonia in idiopathic and secondary forms

Yasuhiro Terasaki
Yasuhiko Nishioka
Takafumi Suda
ResearchOpen Access11 Apr 2025
Scientific Reports

Volume: 15, P: 1-13
pH-responsive disruption of ‘liquid marbles’ prepared from water and poly(6-(acrylamido) hexanoic acid)-grafted silica particles

pH-responsive poly(6-(acrylamido)hexanoic acid)-grafted silica particles (PAaH-SiO₂) were prepared via reversible addition-fragmentation chain transfer (RAFT)-controlled radical polymerization using the chain transfer agent immobilized silica particles. Millimeter-sized ‘liquid marbles’ can be prepared using the pH-responsive PAaH-SiO₂ particles. The ‘liquid marble’ can be transferred intact onto the surface of neutral or acidic water pool, which exhibited long-term stability. When pH of the water pool was changed to alkaline, ‘liquid marble’ burst immediately on the surface of the water pool.

Masamichi Inoue
Syuji Fujii
Shin-ichi Yusa
Research22 Jun 2011
Polymer Journal

Volume: 43, P: 778-784
The effect of lifestyle on the mortality associated with respiratory diseases in the general population

Hiroaki Murano
Sumito Inoue
Masafumi Watanabe
ResearchOpen Access22 May 2023
Scientific Reports

Volume: 13, P: 1-9
SMARCAD1 is an ATP-dependent stimulator of nucleosomal H2A acetylation via CBP, resulting in transcriptional regulation

Masamichi Doiguchi
Takeya Nakagawa
Takashi Ito
ResearchOpen Access18 Feb 2016
Scientific Reports

Volume: 6, P: 1-13
Effect of hyperhomocysteinemia on a murine model of smoke-induced pulmonary emphysema

Hiroshi Nakano
Sumito Inoue
Yoko Shibata
ResearchOpen Access28 Jul 2022
Scientific Reports

Volume: 12, P: 1-13
Microendoscopic calcium imaging of the primary visual cortex of behaving macaques

Mineki Oguchi
Jiang Jiasen
Masamichi Sakagami
ResearchOpen Access23 Aug 2021
Scientific Reports

Volume: 11, P: 1-15
Red blood cell transfusion burden by day 30 predicts mortality in adults after single-unit cord blood transplantation

Takaaki Konuma
Maki Oiwa-Monna
Arinobu Tojo
Research14 May 2019
Bone Marrow Transplantation

Volume: 54, P: 1836-1846
Biological Effects of Anti-RANKL Antibody and Zoledronic Acid on Growth and Tooth Eruption in Growing Mice

Motoki Isawa
Akiko Karakawa
Masamichi Takami
ResearchOpen Access27 Dec 2019
Scientific Reports

Volume: 9, P: 1-11
Predictors for mortality from respiratory failure in a general population

Maki Kobayashi
Yoko Shibata
Isao Kubota
ResearchOpen Access16 May 2016
Scientific Reports

Volume: 6, P: 1-9
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Discovery of a lectin domain that regulates enzyme activity in mouse N-acetylglucosaminyltransferase-IVa (MGAT4A)

X-ray crystallography together with NMR and computer modelling shed light on the structure and catalytic mechanism of GnTIVa, a key enzyme involved in GlcNAc branch synthesis, that bears an unusual C-terminal lectin domain that regulates its catalytic activity.

Masamichi Nagae
Tetsuya Hirata
Yasuhiko Kizuka
ResearchOpen Access19 Jul 2022
Communications Biology

Volume: 5, P: 1-11

Search

FR177391, A New Anti-hyperlipidemic Agent from Serratia

Heterogeneous photocatalytic oxidation of aromatic compounds on TiO₂

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

DOCK2 is involved in the host genetics and biology of severe COVID-19

Blood DNA virome associates with autoimmune diseases and COVID-19

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

Erratum: Rational design of a high-affinity, fast, red calcium indicator R-CaMP2

AID mutant analyses indicate requirement for class-switch-specific cofactors

Separate domains of AID are required for somatic hypermutation and class-switch recombination

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Low-voltage-area ablation for persistent atrial fibrillation: a randomized controlled trial

Spatiotemporal transcriptome analysis reveals critical roles for mechano-sensing genes at the border zone in remodeling after myocardial infarction

Efficacy of combined transbronchial lung cryobiopsy and conventional forceps biopsy for lung malignancies: a prospective cohort study

Acceleration Mechanism of Nucleation of Polymers by Nano-sizing of Nucleating Agent

Microscopically-Viewed Structural Change of Polyethylene during Isothermal Crystallization from the Melt I. Time-Resolved FT-IR Spectral Measurements

In situ class switching and differentiation to IgA-producing cells in the gut lamina propria

Rational design of a high-affinity, fast, red calcium indicator R-CaMP2

Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

New reference values for ultrasound fetal biometry in Japanese population and comparison with other studies

Dzip3 regulates developmental genes in mouse embryonic stem cells by reorganizing 3D chromatin conformation

A prospective cohort study of periostin as a serum biomarker in patients with idiopathic pulmonary fibrosis treated with nintedanib

Diffuse pulmonary ossification and its association with cicatricial organising pneumonia in idiopathic and secondary forms

pH-responsive disruption of ‘liquid marbles’ prepared from water and poly(6-(acrylamido) hexanoic acid)-grafted silica particles

The effect of lifestyle on the mortality associated with respiratory diseases in the general population

SMARCAD1 is an ATP-dependent stimulator of nucleosomal H2A acetylation via CBP, resulting in transcriptional regulation

Effect of hyperhomocysteinemia on a murine model of smoke-induced pulmonary emphysema

Microendoscopic calcium imaging of the primary visual cortex of behaving macaques

Red blood cell transfusion burden by day 30 predicts mortality in adults after single-unit cord blood transplantation

Biological Effects of Anti-RANKL Antibody and Zoledronic Acid on Growth and Tooth Eruption in Growing Mice

Predictors for mortality from respiratory failure in a general population

Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Discovery of a lectin domain that regulates enzyme activity in mouse N-acetylglucosaminyltransferase-IVa (MGAT4A)

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