Nature Search

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
A large-scale magnetic field produced by a solar-like dynamo in binary neutron star mergers

A dynamo mechanism similar to that in the Sun can produce the large-scale magnetic field that is needed to drive the relativistic outflows (and short gamma-ray burst) from binary neutron star mergers, according to a numerical relativity simulation.

Kenta Kiuchi
Alexis Reboul-Salze
Yuichiro Sekiguchi
ResearchOpen Access15 Feb 2024
Nature Astronomy

Volume: 8, P: 298-307
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Differential brain volume between obese and underweight cognitively normal older adults with frailty in the JPSC-AD

Naoki Ishizuka
Hiroshi Akasaka
Yutaka Kiyohara
ResearchOpen Access04 Jun 2025
Scientific Reports

Volume: 15, P: 1-12
High-performance glass filters for capturing and culturing circulating tumor cells and cancer-associated fibroblasts

Hiromasa Tanaka
Daijiro Iwata
Masaru Hori
ResearchOpen Access13 Mar 2023
Scientific Reports

Volume: 13, P: 1-9
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
DMY is a Y-specific DM-domain gene required for male development in the medaka fish

Masaru Matsuda
Yoshitaka Nagahama
Mitsuru Sakaizumi
Research12 May 2002
Nature

Volume: 417, P: 559-563
Equivalent Cross-Relaxation Rate in Magnetic Resonance Imaging. A Novel Physical Parameter for Evaluation of Conditions of Water in Synthetic Copolymer Gels

Shigeru Matsushima
Akinori Takasu
Yasutomi Kinosada
Research01 Mar 2001
Polymer Journal

Volume: 33, P: 236-241
Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer

Colorectal cancer stages are associated with distinct microbial and metabolomic profiles that could shed light on cancer progression.

Shinichi Yachida
Sayaka Mizutani
Takuji Yamada
Research06 Jun 2019
Nature Medicine

Volume: 25, P: 968-976
Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide

5-hydroxythalidomide is a primary thalidomide metabolite generated by the cytochrome P450 isozymes. The reported data, including crystal structure of the 5-hydroxythalidomide-mediated complex of CRBN with SALL4, elucidate how additional hydroxy group of the metabolite enhances the interaction of CRBN with the neosubstrate SALL4.

Hirotake Furihata
Satoshi Yamanaka
Takuya Miyakawa
ResearchOpen Access14 Sept 2020
Nature Communications

Volume: 11, P: 1-11
Visualization of AMPA receptors in living human brain with positron emission tomography

A newly developed PET tracer allows visualization of AMPA receptors in the living human brain, providing a new tool to study their potential involvement in neurological or psychiatric disorders.

Tomoyuki Miyazaki
Waki Nakajima
Takuya Takahashi
Research20 Jan 2020
Nature Medicine

Volume: 26, P: 281-288
Lenalidomide derivatives and proteolysis-targeting chimeras for controlling neosubstrate degradation

Lenalidomide is effective for treating several hematological cancers but has teratogenic effect on the fetus. Here, the authors identify modifications that make lenalidomide more selective and effective when used as a stand-alone molecular glue or integrated in PROTACs.

Satoshi Yamanaka
Hirotake Furihata
Tatsuya Sawasaki
ResearchOpen Access18 Aug 2023
Nature Communications

Volume: 14, P: 1-18
Endoscopic injection sclerotherapy improves liver function compared with endoscopic variceal ligation

Tsuguru Hayashi
Tatsuyuki Watanabe
Masaru Harada
ResearchOpen Access14 Oct 2021
Scientific Reports

Volume: 11, P: 1-7
Low temperature plasma irradiation products of sodium lactate solution that induce cell death on U251SP glioblastoma cells were identified

Hiromasa Tanaka
Yugo Hosoi
Masaru Hori
ResearchOpen Access16 Sept 2021
Scientific Reports

Volume: 11, P: 1-10
Trends in hepatocellular carcinoma incident cases in Japan between 1996 and 2019

Masahito Nakano
Hiroshi Yatsuhashi
Takuji Torimura
ResearchOpen Access27 Jan 2022
Scientific Reports

Volume: 12, P: 1-6
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Saturation Transfer Ratio in Magnetic Resonance Imaging. A Novel Physical Parameter for Evaluation of the Hydrophilicity of Synthetic Copolymer Gels

Shigeru Matsushima
Akinori Takasu
Yasutomi Kinosada
Research01 Oct 2000
Polymer Journal

Volume: 32, P: 828-833
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Glucose metabolism and smaller hippocampal volume in elderly people with normal cognitive function

Ayano Shima
Moeko Noguchi-Shinohara
Yutaka Kiyohara
ResearchOpen Access09 Sept 2024
npj Aging

Volume: 10, P: 1-10
Overexpression of AML1 renders a T hybridoma resistant to T cell receptor-mediated apoptosis

Masami Fujii
Keitaro Hayashi
Masanobu Satake
Research09 Oct 1998
Oncogene

Volume: 17, P: 1813-1820
Green tea consumption and cerebral white matter lesions in community-dwelling older adults without dementia

Shutaro Shibata
Moeko Noguchi-Shinohara
Yutaka Kiyohara
ResearchOpen Access07 Jan 2025
npj Science of Food

Volume: 9, P: 1-8
Plates made from magnesium alloy with a long period stacking ordered structure promote bone formation in a rabbit fracture model

Kosei Takata
Masaki Yugami
Takeshi Miyamoto
ResearchOpen Access10 Apr 2025
Scientific Reports

Volume: 15, P: 1-9
Common protein-altering variant in GFAP is associated with white matter lesions in the older Japanese population

Yoshihiko Furuta
Masato Akiyama
Toshiharu Ninomiya
ResearchOpen Access13 Nov 2024
npj Genomic Medicine

Volume: 9, P: 1-9
POGLUT1, the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.33

Yuki Hitomi
Kazuko Ueno
Minoru Nakamura
ResearchOpen Access14 Jan 2019
Scientific Reports

Volume: 9, P: 1-11
Child–Pugh grade deterioration stratified by the etiology after transcatheter arterial chemoembolization as initial treatment for hepatocellular carcinoma

Kengo Yoshitomi
Tsuguru Hayashi
Yohei Kooka
ResearchOpen Access14 Feb 2024
Scientific Reports

Volume: 14, P: 1-9
Serum high-sensitivity C-reactive protein and dementia in a community-dwelling Japanese older population (JPSC-AD)

Ayumi Tachibana
Jun-ichi Iga
Yutaka Kiyohara
ResearchOpen Access28 Mar 2024
Scientific Reports

Volume: 14, P: 1-9
Transthyretin amyloid deposition in ligamentum flavum (LF) is significantly correlated with LF and epidural fat hypertrophy in patients with lumbar spinal stenosis

Kazuya Maeda
Kazuki Sugimoto
Takeshi Miyamoto
ResearchOpen Access16 Nov 2023
Scientific Reports

Volume: 13, P: 1-8
The IL-17-IL-17RA axis is required to promote osteosarcoma progression in mice

Naoto Yoshimura
Ryusho Kariya
Takeshi Miyamoto
ResearchOpen Access07 Dec 2023
Scientific Reports

Volume: 13, P: 1-13
Long-term effects of ipragliflozin on blood pressure in patients with type 2 diabetes: insights from the randomized PROTECT trial

Yuichi Saito
Atsushi Tanaka
Kosuke Nishio
Research14 Nov 2023
Hypertension Research

Volume: 47, P: 168-176
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Aberrant expression of a novel circular RNA in pancreatic cancer

Takahiro Seimiya
Motoyuki Otsuka
Kazuhiko Koike
Research03 Sept 2020
Journal of Human Genetics

Volume: 66, P: 181-191
Predictors of early remission of proteinuria in adult patients with minimal change disease: a retrospective cohort study

Ryohei Yamamoto
Enyu Imai
Hiroyuki Komatsu
ResearchOpen Access13 Jun 2022
Scientific Reports

Volume: 12, P: 1-12
Estrogen oversees the maintenance of the female genetic program in terminally differentiated gonochorists

B. Paul-Prasanth
R. K. Bhandari
Y. Nagahama
ResearchOpen Access07 Oct 2013
Scientific Reports

Volume: 3, P: 1-11
Identification of genes required for eye development by high-throughput screening of mouse knockouts

Bret Moore et al. from the International Mouse Phenotyping Consortium report the identification of 347 mouse genes that influence ocular phenotypes when knocked out. 75% of the identified genes have not previously been associated with any ocular pathology.

Bret A. Moore
Brian C. Leonard
Ala Moshiri
ResearchOpen Access21 Dec 2018
Communications Biology

Volume: 1, P: 1-12

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