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Showing 1–7 of 7 results
Advanced filters: Author: Mathias Girbig Clear advanced filters

  • This study identifies AcuB as a conserved inhibitor of the deacetylase AcuC in bacteria. AcuB directly suppresses AcuC activity, and this inhibition is enhanced the alarmone diadenosine tetraphosphate, linking stress signaling to acetylation control.

    • Liujuan Zheng
    • Megan K. M. Young
    • Gert Bange
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-15

  • Here the authors structurally investigate elongating human RNA polymerase I at 2.7 Å using cryo-electron microscopy, as well as an RNA polymerase I open complex at 3.3 Å and bound to initiation factor RRN3 at 3.2 Å.

    • Agata D. Misiaszek
    • Mathias Girbig
    • Christoph W. Müller
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 28, P: 997-1008

  • The pluripotency program is maintained by transcription factors from the Sox and POU families. Here they identify SOX and POU factors from unicellular relatives of animals and show that unicellular SOX can replace SOX2 to induce pluripotency, whilst unicellular POU differs from OCT4.

    • Ya Gao
    • Daisylyn Senna Tan
    • Ralf Jauch
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Cryo-EM structures of human Pol III in both apo- and elongating states reveal metazoan-specific differences in the regulation of transcription termination and identify mutations relevant to human disease.

    • Mathias Girbig
    • Agata D. Misiaszek
    • Christoph W. Müller
    Research
    Nature Structural & Molecular Biology
    Volume: 28, P: 210-219

  • Here the authors investigate the regulatory mechanisms of acetyl-CoA (Ac-CoA) biosynthesis in Bacillus subtilis, probing the interaction between acetyl-CoA synthetase (AcsA) and acetyltransferase (AcuA). They capture a stable AcsA-AcuA complex that inhibits AcsA activity in the absence of Ac-CoA.

    • Liujuan Zheng
    • Yifei Du
    • Gert Bange
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • Many enzymes form homo-oligomers, but it is often not clear why. This study follows the evolution self-assembly in citrate synthases across their phylogeny and finds it to be variable and not obviously related to enzyme function.

    • Franziska L. Sendker
    • Tabea Schlotthauer
    • Georg K. A. Hochberg
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Nuclear transcription of a wide variety of RNA species is conducted mainly by three RNA polymerases, which are large and dynamic protein complexes. Recent structural studies have provided important insights into the activities at different transcription stages and the commonalities and differences between these transcription machineries.

    • Mathias Girbig
    • Agata D. Misiaszek
    • Christoph W. Müller
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 23, P: 603-622