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Showing 1–17 of 17 results
Advanced filters: Author: Matthew B. Buechler Clear advanced filters

  • Fibroblast heterogeneity is a prominent but poorly understood feature of solid tumours. Here three major fibroblast subpopulations in non-small cell lung cancer are identified and characterised through single cell RNA-sequencing, multiplexed immunohistochemistry and digital cytometry.

    • Christopher J. Hanley
    • Sara Waise
    • Gareth J. Thomas
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • A preprint by Makris et al. shows that podoplanin is a key regulator of the functions of fibroblastic reticular cells in lymph nodes, by modulating interactions with immune cells.

    • Erika E. McCartney
    • Matthew B. Buechler
    Research Highlights
    Nature Reviews Immunology
    Volume: 25, P: 160

  • Single-cell and genetic tools are used to characterize the diversity of fibroblasts across healthy and perturbed tissues in mice and humans.

    • Matthew B. Buechler
    • Rachana N. Pradhan
    • Shannon. J. Turley
    Research
    Nature
    Volume: 593, P: 575-579

  • A preprint by Sbierski-Kind et al. shows that IL-33-producing adventitial fibroblasts provide a stromal niche for ILC2s that limits IL-17-mediated liver fibrosis.

    • Anthony Altieri
    • Matthew B. Buechler
    Research Highlights
    Nature Reviews Immunology
    Volume: 23, P: 477

  • The integration of liver and plasma quantitative lipidomic and proteomic data from 107 distinct mouse strains provides important insights into regulators of mammalian lipid metabolism.

    • Benjamin L. Parker
    • Anna C. Calkin
    • Brian G. Drew
    Research
    Nature
    Volume: 567, P: 187-193

  • Peyer’s patches (PPs) are sites of antibody production in the gut mucosa. Carroll and colleagues show the mechanosensory channel protein Piezo1 is required for the homeostatic maintenance of PPs. Specific loss of Piezo1 in FRCs disrupt PP structure and function, resulting in reduction of fecal IgA production and gut immunity.

    • Jonathan E. Chang
    • Matthew B. Buechler
    • Michael C. Carroll
    Research
    Nature Immunology
    Volume: 20, P: 1506-1516

  • Testosterone deficiency is associated with autoimmunity and increased B cell numbers, but the underlying mechanism is unclear. Here the authors show that testosterone may modulate the production of B cell survival factor BAFF by fibroblastic reticular cells via regulation of splenic neurotransmitter levels.

    • Anna S. Wilhelmson
    • Marta Lantero Rodriguez
    • Åsa Tivesten
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Zika virus (ZIKV) is present in body fluids, including saliva, but transmission risk through mucosal contact is not well known. Here, the authors show that oropharyngeal mucosal infection of macaques with a high ZIKV dose results in viremia, but that transmission risk from saliva of infected animals is low.

    • Christina M. Newman
    • Dawn M. Dudley
    • Thomas C. Friedrich
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-7

  • Helper T cell subsets are characterized functionally by the cytokines they produce. Benoist and colleagues demonstrate that in vivo helper T cells do not manifest as discrete helper subsets but rather form a continuum shaped by microbial exposure.

    • Evgeny Kiner
    • Elijah Willie
    • Hideyuki Yoshida
    Research
    Nature Immunology
    Volume: 22, P: 216-228

  • Differentiating neutrophil functional states is difficult. Here the authors show, using single cell RNA-sequencing and trajectory analyses, that mouse neutrophils can be presented as a transcriptome continuum rather than discrete subsets, but are affected by inflammation to express distinct transcriptional states.

    • Ricardo Grieshaber-Bouyer
    • Felix A. Radtke
    • Hideyuki Yoshida
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-21

  • Using whole-genome data for single-nucleotide polymorphism and results from genome-wide association studies, the authors show that people’s preference for pairing with those with similar phenotypic traits has genetic causes and consequences.

    • Matthew R. Robinson
    • Aaron Kleinman
    • Peter M. Visscher
    Research
    Nature Human Behaviour
    Volume: 1, P: 1-13

  • Brown and colleagues generated an atlas of miRNA expression profiles from primary mouse immune cell populations and connected these signatures with ATAC–seq, ChIP–seq and nascent RNA profiles to establish a map of miRNA promoter and enhancer usage in immune cells.

    • Samuel A. Rose
    • Aleksandra Wroblewska
    • Aldrin Yim
    Research
    Nature Immunology
    Volume: 22, P: 914-927

  • Nature Immunology’s 20th anniversary is a good opportunity to reminisce about the ImmGen collective endeavor — its goals, successes and horror stories — and the group’s exploration of various modes of scientific publishing.

    • Stephanie Vargas Aguilar
    • Oscar Aguilar
    • Caroline Ziemkiewicz
    Comments & Opinion
    Nature Immunology
    Volume: 21, P: 700-703