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Showing 1–3 of 3 results
Advanced filters: Author: Matthew Goddeeris Clear advanced filters

  • Drug-induced liver injury is a major cause of patient harm, trial failures, and drug withdrawals. Here, the authors show that a toxicogenomics resource of 300 drugs enables the prediction of liver injury with 88% sensitivity at 100% specificity and reveals mechanisms for safer drug development.

    • Volker Bergen
    • Konstantia Kodella
    • Mahdi Zamanighomi
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • This study finds a direct correlation between LARGE-glycan extension on dystroglycan and the protein’s capacity for extracellular matrix ligands; in regenerating mouse muscle, short LARGE-glycan polysaccharides cause various defects, including muscle dysfunction and a predisposition to dystrophy, and in muscular dystrophy patients, increased clinical severity of disease corresponds to shorter LARGE-glycans.

    • Matthew M. Goddeeris
    • Biming Wu
    • Kevin P. Campbell
    Research
    Nature
    Volume: 503, P: 136-140