The sustainable and scalable synthesis of chiral amines remains a significant challenge in industrial chemistry, particularly due to the limitations of current biocatalytic processes in achieving high productivity and selectivity at scale. This study reports a dynamic kinetic resolution strategy that integrates flash thermal racemization with enzymatic resolution in a continuous flow system, achieving unprecedented productivity, excellent enantioselectivity, and industry-relevant green chemistry metrics at scales up to 100 grams.
- Matthew J. Takle
- David M. Maurer
- King Kuok Mimi Hii
