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Showing 1–2 of 2 results
Advanced filters: Author: Matthew L. Condakes Clear advanced filters

  • KRAS is an oncogene that switches between a GDP-bound inactive state and a GTP-bound active state. Recently developed KRAS G12C inhibitors are specific to the GDP-bound inactive state. Here, the authors develop a class of covalent KRAS G12C inhibitors capable of targeting both states for the treatment of KRAS-driven cancer.

    • Matthew L. Condakes
    • Zhuo Zhang
    • Michelle L. Stewart
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-15

  • A practical, fully synthetic route to macrolide antibiotics via the convergent assembly of simple chemical building blocks is described; more than 300 new macrolide antibiotic candidates have been synthesized using this approach, a number of which are active against bacterial strains that are resistant to currently used antibiotics.

    • Ian B. Seiple
    • Ziyang Zhang
    • Andrew G. Myers
    Research
    Nature
    Volume: 533, P: 338-345