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Showing 1–8 of 8 results
Advanced filters: Author: Matthew L. Hemming Clear advanced filters

  • New proxy data for ocean pH and an ocean–atmosphere model show that a radically different ocean circulation led to decoupling of ocean productivity and upwelling in the equatorial Pacific Ocean 3–6 million years ago.

    • Madison G. Shankle
    • Natalie J. Burls
    • Pincelli M. Hull
    Research
    Nature
    Volume: 598, P: 457-461

  • A genome-wide study by the Long COVID Host Genetics Initiative identifies an association between the FOXP4 locus and long COVID, implicating altered lung function in its pathophysiology.

    • Vilma Lammi
    • Tomoko Nakanishi
    • Hanna M. Ollila
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 1402-1417

  • The East Antarctic ice sheet is considered to be largely insensitive to temperature changes in the Southern Ocean. Marine sediment records indicate the East Antarctic ice sheet repeatedly retreated by several hundred kilometres during intervals of Pliocene warmth.

    • Carys P. Cook
    • Tina van de Flierdt
    • Masako Yamane
    Research
    Nature Geoscience
    Volume: 6, P: 765-769

  • An ensemble of experiments is used with a global climate model to assess the contribution of plant 'physiological forcing' to future changes in continental runoff. It is found that the effect increases simulated global mean runoff by 6 per cent when the concentration of carbon dioxide is doubled relative to pre-industrial levels; an increase that is comparable to that simulated in response to climate change caused by radiative forcing. This finding suggests that the risk of flooding may be greater than previously assumed under future global warming scenarios.

    • Richard A. Betts
    • Olivier Boucher
    • Mark J. Webb
    Research
    Nature
    Volume: 448, P: 1037-1041

  • Gastrointestinal stromal tumours can be initiated by gain-of-function mutations of the KIT or PDGFRA oncogenes but also by loss of the metabolic complex succinate dehydrogenase (SDH), which leads to DNA hypermethylation; this study shows that in SDH-deficient tumours, displacement of CTCF insulators by DNA methylation activates oncogene expression, illustrating how epigenetic alterations can drive oncogenic signalling in the absence of kinase mutations.

    • William A. Flavahan
    • Yotam Drier
    • Bradley E. Bernstein
    Research
    Nature
    Volume: 575, P: 229-233