A genome-wide RNAi synthetic lethal screen unravels the role of p53 in small nucleolar RNPs (snoRNPs) through a genetic interaction with UNRIP, which has been previously shown to interact with the snoRNP chaperone SMN. p53 regulates the levels of Nolc1, which affects snoRNP stability, whereas UNRIP contributes to nuclear SMN import, revealing a synergistic requirement for both in snoRNP assembly.
- Dragomir B. Krastev
- Mikolaj Slabicki
- Frank Buchholz
