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Fluoroform upcycling to trifluorovinylamine as a C2 reagent to prepare difluoromethylated molecules

Fluoroform (HFC-23) is a potent greenhouse gas by-product produced in multi-tonne quantities. Here the valorization of HFC-23 into a fluorinated C2 reagent, trifluorovinylamine, which can be used in transformations to prepare fluorinated molecules, is reported.

Pavel Ivashkin
Jonathan Decaens
Philippe Jubault
Research23 Mar 2026
Nature Synthesis

P: 1-8

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Fluoroform upcycling to trifluorovinylamine as a C2 reagent to prepare difluoromethylated molecules

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