Nature Search

Genetic influences on brain structure

Paul M. Thompson
Tyrone D. Cannon
Arthur W. Toga
Research05 Nov 2001
Nature Neuroscience

Volume: 4, P: 1253-1258
Strategies to control humidity sensitivity of azobenzene isomerisation kinetics in polymer thin films

Many variables related to azobenzene-based humidity sensors remain. Here, a small library of tautomerisable azobenzenes is studied for their humidity dependent thermal isomerisation rate in polymer thin films.

Sami Vesamäki
Henning Meteling
Arri Priimagi
ResearchOpen Access02 Oct 2024
Communications Materials

Volume: 5, P: 1-11
Targeting sex steroid biosynthesis for breast and prostate cancer therapy

Sex steroids are major promoters of the growth of breast and prostate cancers. This Review by Poutanen et al. describes the development of treatments for these cancer types that act to restrict sex steroid availability for receptor binding by inhibiting steroid biosynthesis, being a complementary mechanism of action to the more traditional sex steroid antagonists.

Matti Poutanen
Malin Hagberg Thulin
Pirkko Härkönen
Reviews08 Sept 2023
Nature Reviews Cancer

Volume: 23, P: 686-709
Superior metabolic improvement of polycystic ovary syndrome traits after GLP1-based multi-agonist therapy

Metabolic complications are common in patients suffering PCOS, including obesity, insulin resistance and type-2 diabetes. Here the authors show the efficacy of GLP1-based multi-agonists, and superiority of GLP1/E, for managing metabolic complications of PCOS in preclinical models, with improvement also of some reproductive traits.

Miguel A. Sánchez-Garrido
Víctor Serrano-López
Manuel Tena-Sempere
ResearchOpen Access01 Oct 2024
Nature Communications

Volume: 15, P: 1-20
Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction

SUMOylation is known to regulate androgen receptor (AR) activity in cultured cells. Here, using SUMOylation-deficient AR knock-in mice, the authors demonstrate that SUMOylation is required for AR-related gene expression specifically in the epididymal tissues, but not the testis.

Fu-Ping Zhang
Marjo Malinen
Jorma J. Palvimo
ResearchOpen Access15 Feb 2019
Nature Communications

Volume: 10, P: 1-12
Optimized design and analysis of preclinical intervention studies in vivo

Teemu D. Laajala
Mikael Jumppanen
Tero Aittokallio
ResearchOpen Access02 Aug 2016
Scientific Reports

Volume: 6, P: 1-13
Dicer ablation in Kiss1 neurons impairs puberty and fertility preferentially in female mice

Kiss1 neurons are essential for puberty and fertility. Here, the authors show that canonical microRNA biosynthesis in Kiss1 neurons plays an essential role in the control of puberty and fertility, especially in females, likely via repression of repressors on the Kiss1 gene.

Juan Roa
Miguel Ruiz-Cruz
Manuel Tena-Sempere
ResearchOpen Access09 Aug 2022
Nature Communications

Volume: 13, P: 1-19
Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer

SPINK1 upregulation is found in ~10–25% of prostate cancers. Here, they show that whilst SPINK1 is transcriptionally repressed by androgen receptor and its co-repressor REST, it is upregulated after androgen-deprivation therapy, which leads to neuroendocrine differentiation of prostate cancer cells.

Ritika Tiwari
Nishat Manzar
Bushra Ateeq
ResearchOpen Access20 Jan 2020
Nature Communications

Volume: 11, P: 1-19
Male pheromone–stimulated neurogenesis in the adult female brain: possible role in mating behavior.

Gloria K Mak
Emeka K Enwere
Samuel Weiss
Research01 Jul 2007
Nature Neuroscience

Volume: 10, P: 1003-1011
Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures

A new study shows that Wnt16 inhibits osteoclast formation, suggesting it may be a possible therapeutic option for treating bone fractures in osteoporosis.

Sofia Movérare-Skrtic
Petra Henning
Claes Ohlsson
Research12 Oct 2014
Nature Medicine

Volume: 20, P: 1279-1288
Deleting the mouse Hsd17b1 gene results in a hypomorphic Naglu allele and a phenotype mimicking a lysosomal storage disease

Heli Jokela
Janne Hakkarainen
Matti Poutanen
ResearchOpen Access27 Nov 2017
Scientific Reports

Volume: 7, P: 1-12
A Common Polymorphism in the Human Relaxin-Like Factor (RLF) Gene: No Relationship with Cryptorchidism

Pasi Koskimies
Helena Virtanen
Jorma Toppari
Research01 Apr 2000
Pediatric Research

Volume: 47, P: 538-541
Fetal but not adult Leydig cells are susceptible to adenoma formation in response to persistently high hCG level: a study on hCG overexpressing transgenic mice

Petteri Ahtiainen
Susana B Rulli
Ilpo T Huhtaniemi
Research11 Jul 2005
Oncogene

Volume: 24, P: 7301-7309
Glucocorticoid receptor-induced non-muscle caldesmon regulates metastasis in castration-resistant prostate cancer

Verneri Virtanen
Kreetta Paunu
Maria Sundvall
ResearchOpen Access12 Aug 2023
Oncogenesis

Volume: 12, P: 1-12
A relational database to identify differentially expressed genes in the endometrium and endometriosis lesions

Michael Gabriel
Vidal Fey
Matti Poutanen
ResearchOpen Access28 Aug 2020
Scientific Data

Volume: 7, P: 1-13
Glycovariant-based lateral flow immunoassay to detect ovarian cancer–associated serum CA125

Sherif Bayoumy et al. report a lateral flow immunoassay (LFIA) to quantify aberrantly glycosylated CA125 to diagnose epithelial ovarian cancer. Their method has a 30-minute read-out time, high sensitivity and specificity, and can distinguish ovarian cancer from benign endometriosis and other cancers.

Sherif Bayoumy
Heidi Hyytiä
Kim Pettersson
ResearchOpen Access21 Aug 2020
Communications Biology

Volume: 3, P: 1-7
Increased estrogen to androgen ratio enhances immunoglobulin levels and impairs B cell function in male mice

Juan Antonio Aguilar-Pimentel
Yi-Li Cho
Leena Strauss
ResearchOpen Access27 Oct 2020
Scientific Reports

Volume: 10, P: 1-14
Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty

Teresa Elo
Päivi H. Lindfors
Marja L. Mikkola
ResearchOpen Access11 Jul 2017
Scientific Reports

Volume: 7, P: 1-13
High levels of luteinizing hormone analog stimulate gonadal and adrenal tumorigenesis in mice transgenic for the mouse inhibin-α-subunit promoter/Simian virus 40 T-antigen fusion gene

Maarit Mikola
Jukka Kero
Ilpo Huhtaniemi
Research22 May 2003
Oncogene

Volume: 22, P: 3269-3278

Search

Genetic influences on brain structure

Strategies to control humidity sensitivity of azobenzene isomerisation kinetics in polymer thin films

Targeting sex steroid biosynthesis for breast and prostate cancer therapy

Superior metabolic improvement of polycystic ovary syndrome traits after GLP1-based multi-agonist therapy

Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction

Optimized design and analysis of preclinical intervention studies in vivo

Dicer ablation in Kiss1 neurons impairs puberty and fertility preferentially in female mice

Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer

Male pheromone–stimulated neurogenesis in the adult female brain: possible role in mating behavior.

Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures

Deleting the mouse Hsd17b1 gene results in a hypomorphic Naglu allele and a phenotype mimicking a lysosomal storage disease

A Common Polymorphism in the Human Relaxin-Like Factor (RLF) Gene: No Relationship with Cryptorchidism

Fetal but not adult Leydig cells are susceptible to adenoma formation in response to persistently high hCG level: a study on hCG overexpressing transgenic mice

Glucocorticoid receptor-induced non-muscle caldesmon regulates metastasis in castration-resistant prostate cancer

A relational database to identify differentially expressed genes in the endometrium and endometriosis lesions

Glycovariant-based lateral flow immunoassay to detect ovarian cancer–associated serum CA125

Increased estrogen to androgen ratio enhances immunoglobulin levels and impairs B cell function in male mice

Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty

High levels of luteinizing hormone analog stimulate gonadal and adrenal tumorigenesis in mice transgenic for the mouse inhibin-α-subunit promoter/Simian virus 40 T-antigen fusion gene

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