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Nature Immunology (2)

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Tissue-resident exhausted and memory CD8⁺ T cells have distinct ontogeny, function and roles in disease

Here the authors show that persistent antigen stimulation drives the generation of CD8⁺ tissue-resident exhausted T cells with distinct developmental origins, function and therapeutic responsiveness when compared to CD8⁺ tissue-resident memory T cells.

Simone L. Park
Mark M. Painter
E. John Wherry
Research29 Dec 2025
Nature Immunology

Volume: 27, P: 110-125
Publisher Correction: Tissue-resident exhausted and memory CD8⁺ T cells have distinct ontogeny, function and roles in disease

Simone L. Park
Mark M. Painter
E. John Wherry
Amendments and Corrections13 Jan 2026
Nature Immunology

P: 1

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Tissue-resident exhausted and memory CD8+ T cells have distinct ontogeny, function and roles in disease

Publisher Correction: Tissue-resident exhausted and memory CD8+ T cells have distinct ontogeny, function and roles in disease

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Tissue-resident exhausted and memory CD8⁺ T cells have distinct ontogeny, function and roles in disease

Publisher Correction: Tissue-resident exhausted and memory CD8⁺ T cells have distinct ontogeny, function and roles in disease