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Showing 1–3 of 3 results
Advanced filters: Author: Maximilian D. Palkowitz Clear advanced filters

  • Molecular scaffolds bearing 1,1-diaryl-substituted four-membered rings remain difficult to access using traditional synthesis. Now it has been shown that a modular, nickel-electrocatalytic sequence enables the programmable, scalable and chemoselective synthesis of these high-value motifs, offering broad utility across drug discovery and showcasing strategic applications to patented intermediates.

    • Luca Massaro
    • Philipp Neigenfind
    • Phil S. Baran
    Research
    Nature Chemistry
    P: 1-9

  • We report a radical-based Ni/Ag-electrocatalytic cross-coupling of substituted carboxylic acids, enabling an approach to accessing complex molecular architectures, which relies on a silver additive that forms an active Ag nanoparticle-coated electrode surface along with carefully chosen ligands.

    • Benxiang Zhang
    • Jiayan He
    • Phil S. Baran
    Research
    Nature
    Volume: 623, P: 745-751

  • Electrophilic halogenation approaches often suffer from low reactivity and chemoselectivity when it comes to complex compounds. Now a class of halogenating reagents based on anomeric amides that can halogenate complex bioactive molecules with diverse functional groups and heterocycles has been developed. The higher reactivity of these anomeric amide reagents is attributed to the energy stored in the pyramidalized nitrogen.

    • Yu Wang
    • Cheng Bi
    • Phil S. Baran
    Research
    Nature Chemistry
    Volume: 16, P: 1539-1545