Nature Search

C-COMPASS: a user-friendly neural network tool profiles cell compartments at protein and lipid levels

C-COMPASS is an open-source software designed to predict the spatial cellular distribution of proteins and lipids from cellular organelle profiling using a neural network-based regression model.

Daniel T. Haas
Daniel Weindl
Natalie Krahmer
ResearchOpen Access04 Dec 2025
Nature Methods

Volume: 23, P: 118-130
Towards fair decentralized benchmarking of healthcare AI algorithms with the Federated Tumor Segmentation (FeTS) challenge

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Maximilian Zenk
Ujjwal Baid
Spyridon Bakas
ResearchOpen Access08 Jul 2025
Nature Communications

Volume: 16, P: 1-20
Genomic investigations of unexplained acute hepatitis in children

An investigation using various methods reports an association between adeno-associated virus 2 and paediatric hepatitis of unknown aetiology.

Sofia Morfopoulou
Sarah Buddle
Judith Breuer
ResearchOpen Access30 Mar 2023
Nature

Volume: 617, P: 564-573
Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

Seung Hoan Choi
Sean J. Jurgens
Patrick T. Ellinor
Research06 Mar 2025
Nature Genetics

Volume: 57, P: 548-562
Federated learning enables big data for rare cancer boundary detection

Federated ML (FL) provides an alternative to train accurate and generalizable ML models, by only sharing numerical model updates. Here, the authors present the largest FL study to-date to generate an automatic tumor boundary detector for glioblastoma.

Sarthak Pati
Ujjwal Baid
Spyridon Bakas
ResearchOpen Access05 Dec 2022
Nature Communications

Volume: 13, P: 1-17
Single-particle cryo-EM structures from iDPC–STEM at near-atomic resolution

This paper explores the use of scanning transmission electron microscopy (STEM) to vitrified biological samples for biomolecular structure elucidation. Integrated differential phase contrast (iDPC)–STEM imaging of keyhole limpet hemocyanin and tobacco mosaic virus enabled cryo-EM structure determination at 6.5 and 3.5 Å resolution, respectively.

Ivan Lazić
Maarten Wirix
Carsten Sachse
ResearchOpen Access05 Sept 2022
Nature Methods

Volume: 19, P: 1126-1136
Structural covariance network topology in individuals at clinical high risk for psychosis: the ENIGMA-CHR Study

Siwei Liu
Ingrid Agartz
Therese AMJ van Amelsvoort
ResearchOpen Access22 Oct 2025
Molecular Psychiatry

P: 1-16
Exome sequencing points to pathogenic ATM variants in gastric cancer

Laura L. Koebbe
Timo Hess
Johannes Schumacher
ResearchOpen Access26 Dec 2025
European Journal of Human Genetics

P: 1-6
NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart

Phosphorylation of the essential myosin light chain (ELC) influence actin-myosin crossbridge cycling in the heart. Here, the authors show upregulated ELC-phosphorylation in systolic heart failure and identify NIMArelated kinase 9 to bind to ELC mediating its calcium-dependent phosphorylation.

Marion Müller
Rose Eghbalian
Benjamin Meder
ResearchOpen Access20 Oct 2022
Nature Communications

Volume: 13, P: 1-18
Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein

Folliculin is a known tumour suppressor but the molecular mechanisms behind this function are unclear. Here the authors show that Folliculin regulates EGFR signalling by modulating its Rab7a-dependent trafficking.

Laura A. Laviolette
Julien Mermoud
Othon Iliopoulos
ResearchOpen Access28 Jun 2017
Nature Communications

Volume: 8, P: 1-14
The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension

The ABL-ERK-MYC signaling axis inhibits WIPI1 gene expression, thereby controlling the autophagy-enhancing effect of WIPI1 in the context of C. elegans lifespan control.

Katharina Sporbeck
Maximilian L. Haas
Tassula Proikas-Cezanne
ResearchOpen Access24 Aug 2023
Communications Biology

Volume: 6, P: 1-23
Pattern of predictive features of continued cannabis use in patients with recent-onset psychosis and clinical high-risk for psychosis

Nora Penzel
Rachele Sanfelici
Henrik Rohner
ResearchOpen Access09 Mar 2022
Schizophrenia

Volume: 8, P: 1-11
Association between age of cannabis initiation and gray matter covariance networks in recent onset psychosis

Nora Penzel
Linda A. Antonucci
Henrik Rohner
ResearchOpen Access03 Mar 2021
Neuropsychopharmacology

Volume: 46, P: 1484-1493
Formation of a transient amorphous solid in low density aqueous charged sphere suspensions

Ran Niu
Sabrina Heidt
Thomas Palberg
ResearchOpen Access06 Dec 2017
Scientific Reports

Volume: 7, P: 1-15
Transdiagnostic subgroups of cognitive impairment in early affective and psychotic illness

Julian Wenzel
Luzie Badde
Henrik Rohner
ResearchOpen Access22 Sept 2023
Neuropsychopharmacology

Volume: 49, P: 573-583
Super-resolution microscopy with DNA-PAINT

In DNA-PAINT, transient binding of dye-labeled oligonucleotides to their target strands creates the ‘blinking’ required for stochastic nanoscopy. This protocol describes how to apply DNA-PAINT, from sample preparation to data processing.

Joerg Schnitzbauer
Maximilian T Strauss
Ralf Jungmann
Protocols18 May 2017
Nature Protocols

Volume: 12, P: 1198-1228
Author Correction: Federated learning enables big data for rare cancer boundary detection

Sarthak Pati
Ujjwal Baid
Spyridon Bakas
Amendments and CorrectionsOpen Access26 Jan 2023
Nature Communications

Volume: 14, P: 1-2
Real-world experience of CPX-351 as first-line treatment for patients with acute myeloid leukemia

Christina Rautenberg
Friedrich Stölzel
Jan Moritz Middeke
ResearchOpen Access04 Oct 2021
Blood Cancer Journal

Volume: 11, P: 1-8
Multivariate pattern analysis of brain structure predicts functional outcome after auditory-based cognitive training interventions

Lana Kambeitz-Ilankovic
Sophia Vinogradov
Karuna Subramaniam
ResearchOpen Access19 Aug 2021
npj Schizophrenia

Volume: 7, P: 1-8
Next Generation Driver for Attosecond and Laser-plasma Physics

D. E. Rivas
A. Borot
L. Veisz
ResearchOpen Access12 Jul 2017
Scientific Reports

Volume: 7, P: 1-8
Cause of death after allogeneic haematopoietic stem cell transplantation (HSCT) in early leukaemias: an EBMT analysis of lethal infectious complications and changes over calendar time

A Gratwohl
R Brand
C Cordonnier
Special Features05 Sept 2005
Bone Marrow Transplantation

Volume: 36, P: 757-769

Search

C-COMPASS: a user-friendly neural network tool profiles cell compartments at protein and lipid levels

Towards fair decentralized benchmarking of healthcare AI algorithms with the Federated Tumor Segmentation (FeTS) challenge

Genomic investigations of unexplained acute hepatitis in children

Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk

Federated learning enables big data for rare cancer boundary detection

Single-particle cryo-EM structures from iDPC–STEM at near-atomic resolution

Structural covariance network topology in individuals at clinical high risk for psychosis: the ENIGMA-CHR Study

Exome sequencing points to pathogenic ATM variants in gastric cancer

NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart

Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein

The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension

Pattern of predictive features of continued cannabis use in patients with recent-onset psychosis and clinical high-risk for psychosis

Association between age of cannabis initiation and gray matter covariance networks in recent onset psychosis

Formation of a transient amorphous solid in low density aqueous charged sphere suspensions

Transdiagnostic subgroups of cognitive impairment in early affective and psychotic illness

Super-resolution microscopy with DNA-PAINT

Author Correction: Federated learning enables big data for rare cancer boundary detection

Real-world experience of CPX-351 as first-line treatment for patients with acute myeloid leukemia

Multivariate pattern analysis of brain structure predicts functional outcome after auditory-based cognitive training interventions

Next Generation Driver for Attosecond and Laser-plasma Physics

Cause of death after allogeneic haematopoietic stem cell transplantation (HSCT) in early leukaemias: an EBMT analysis of lethal infectious complications and changes over calendar time

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