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Showing 1–2 of 2 results
Advanced filters: Author: Megan Balzarini Clear advanced filters

  • In this study, Vande Voorde et al. investigate the potential of untargeted metabolomics as a stratification tool for colorectal cancer (CRC). They present a comprehensive pipeline to uncover metabolic vulnerabilities in CRC based on its genetic origin. With this approach, they show perturbations in methionine metabolism linked to APC deficiency, and identify adenosylhomocysteinase as an actionable therapeutic target.

    • Johan Vande Voorde
    • Rory T. Steven
    • Owen J. Sansom
    ResearchOpen Access
    Nature Metabolism
    Volume: 5, P: 1303-1318