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Showing 1–3 of 3 results
Advanced filters: Author: Megan Korn Clear advanced filters

  • This study shows how Escherichia coli ApaH hydrolyzes enigmatic Np4N alarmones and decaps Np4-capped RNAs, thereby impacting their lifetimes. Key features enable ApaH to bind RNA substrates in two orientations, depending on the cap and the first RNA nucleotide.

    • Ashok Nuthanakanti
    • Megan Korn
    • Alexander Serganov
    Research
    Nature Chemical Biology
    P: 1-11

  • Decreased brain coenzyme Q10 levels cause encephalopathy and are associated with neurodegeneration; supplementation with 4-HMA or 4-HB restores coenzyme Q10 synthesis in mice and humans with HPDL variants, improving survival and neurological symptoms in HPDL-driven mitochondrial encephalopathy.

    • Guangbin Shi
    • Claire Miller
    • Michael E. Pacold
    ResearchOpen Access
    Nature
    Volume: 645, P: 466-474

  • A high-throughput chemical–genetic screening approach for the discovery of targets and chemicals to treat Mycobacterium tuberculosis yields tenfold more hit compounds than conventional whole-cell screening methods.

    • Eachan O. Johnson
    • Emily LaVerriere
    • Deborah T. Hung
    Research
    Nature
    Volume: 571, P: 72-78