The authors show that there is global loss of heterochromatin in tau transgenic Drosophila and mice, and post-mortem brain from Alzheimer's disease patients. Oxidative stress and DNA damage mechanistically link tau and heterochromatin loss. Finally, they show that reversing tau-induced heterochromatin loss reduces neurodegeneration in tau transgenic Drosophila.
- Bess Frost
- Martin Hemberg
- Mel B Feany
