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Advanced filters: Author: Melissa Ellermann Clear advanced filters

Biosynthetic enzyme analysis identifies a protective role for TLR4-acting gut microbial sulfonolipids in inflammatory bowel disease

Human microbes biosynthesize functional metabolites to influence human health. Here, the authors link the biosynthesis of microbial sulfonolipids (SoLs) to inflammatory bowel diseases, and reveal that SoLs block LPS binding to TLR4, suppressing LPS-induced inflammation.

Ethan A. Older
Jian Zhang
Jie Li
ResearchOpen Access30 Oct 2024
Nature Communications

Volume: 15, P: 1-17
Diet-derived galacturonic acid regulates virulence and intestinal colonization in enterohaemorrhagic Escherichia coli and Citrobacter rodentium

Galacturonic acid produced by Bacteroides thetaiotamicron is shown to be sensed by enterohaemorrhagic Escherichia coli and Citrobacter rodentium to initiate an infection program that includes its use as a carbon source and regulation of the type III secretion system, leading to colitis and inflammation.

Angel G. Jimenez
Melissa Ellermann
Vanessa Sperandio
Research23 Dec 2019
Nature Microbiology

Volume: 5, P: 368-378
A pilot study to assess the healing of meniscal tears in young adult goats

William Fedje-Johnston
Casey P. Johnson
Marc Tompkins
ResearchOpen Access09 Jul 2021
Scientific Reports

Volume: 11, P: 1-12

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