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The S-depalmitoylase ABHD10 is essential for sperm mitochondrial sheath formation and male fertility

This study demonstrates that ABHD10, a mitochondrial depalmitoylase, is indispensable for male fertility in mice. ABHD10 deficiency causes sperm motility defects by disrupting mitochondrial sheath formation and oxidative phosphorylation.

Shumin Zhou
Hao Zhou
Fei Sun
ResearchOpen Access24 Nov 2025
Nature Communications

Volume: 16, P: 1-19

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The S-depalmitoylase ABHD10 is essential for sperm mitochondrial sheath formation and male fertility

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