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Showing 1–16 of 16 results

Advanced filters: Author: Mengyue Zhao Clear advanced filters

USP10 promotes glioma stem cell maintenance and glioblastoma growth by antagonizing DTX3L-mediated SATB2 ubiquitination

Dysregulation in proteolysis contributes to brain tumorigenesis. Here the authors report that USP10 deubiquitinase is enriched in glioma stem cells (GSCs), which antagonizes DTX3L-mediated ubiquitination of SATB2, a major driver of GSC proliferation and self-renewal.

Mengyue Guo
Wenlong Luo
Weiwei Tao
ResearchOpen Access08 Jan 2026
Nature Communications

Volume: 17, P: 1-19
Visible light-promoted CO₂ fixation with imines to synthesize diaryl α-amino acids

Fixation of CO₂ in organic molecules is an area of great interest due to the implications in sustainable chemistry. Here, the authors show a visible light-mediated hydrocarboxylation of ketimines with atmospheric CO₂ to afford a number of α,α–diaryl α-amino acid derivatives.

Xinyuan Fan
Xu Gong
Patrick J. Walsh
ResearchOpen Access22 Nov 2018
Nature Communications

Volume: 9, P: 1-8
Transcriptomic and spatial GABAergic neuron subtypes in zona incerta mediate distinct innate behaviors

Here, authors show the behavioral function of two transcriptomic GABAergic neuron subtypes in the zona incerta by integrating single-nucleus sequencing, circuit mapping, and optogenetics, advancing our understanding of functional brain organization.

Mengyue Zhu
Jieqiao Peng
Jiadong Chen
ResearchOpen Access01 Apr 2025
Nature Communications

Volume: 16, P: 1-19
Regulation of m⁶A RNA reader protein OsECT3 activity by lysine acetylation in the cold stress response in rice

Ma et al. report a regulatory mechanism by which lysine acetylation of the m⁶A reader protein OsECT3 modulates its m⁶A-binding activity under cold stress. The reduced acetylation level stabilizes cold-responsive mRNAs to enhance cold tolerance in rice.

Nini Ma
Peizhe Song
Yu Zhao
Research20 Jun 2025
Nature Plants

Volume: 11, P: 1165-1180
The genomic landscape of Epstein-Barr virus-associated pulmonary lymphoepithelioma-like carcinoma

The rare lung cancer subtype pulmonary lymphoepithelioma-like carcinoma is linked to Epstein-Barr virus infection. Here, the authors provide a mutational landscape for this cancer, showing a low burden of somatic mutations and high prevalence of copy number variations.

Shaodong Hong
Dongbing Liu
Li Zhang
ResearchOpen Access16 Jul 2019
Nature Communications

Volume: 10, P: 1-12
Strand-preferred base editing of organellar and nuclear genomes using CyDENT

A TALE-based modular base editing system shows high strand specificity in multiple organelles.

Jiacheng Hu
Yu Sun
Caixia Gao
Research28 Aug 2023
Nature Biotechnology

Volume: 42, P: 936-945
GmERF13 mediates salt inhibition of nodulation through interacting with GmLBD16a in soybean

Salt stress inhibits legume nodulation. Here it is reported that mutants of a transcription factor gene GmERF13 alleviate this inhibitory effect. Further investigations reveal the mechanisms by which GmERF13 is regulated by salt stress and GmERF13 regulates nodule formation.

Xinfang Zhu
Xifeng Yan
Zhaojun Ding
ResearchOpen Access06 Jan 2025
Nature Communications

Volume: 16, P: 1-18
Large Stokes shift fluorescent RNAs for dual-emission fluorescence and bioluminescence imaging in live cells

The Clivias are a series of small, monomeric fluorescent RNAs that emit with a large Stokes shift in the orange–red. They enable multiplexed RNA imaging in live cells and BRET-based detection of protein–RNA interactions in mice.

Li Jiang
Xin Xie
Yi Yang
Research18 Sept 2023
Nature Methods

Volume: 20, P: 1563-1572
Mutant Kras co-opts a proto-oncogenic enhancer network in inflammation-induced metaplastic progenitor cells to initiate pancreatic cancer

David and colleagues uncover an inflammation-activated, progenitor-derived enhancer network hijacked by mutant Kras during pancreatic cancer initiation.

Yong Li
Yi He
Charles J. David
Research02 Nov 2020
Nature Cancer

Volume: 2, P: 49-65
ALDH1A3 promotes aggressive basal-like pancreatic cancer through an AP-1/RUNX2 enhancer network

Xiaoping Zou
Shuang Nie
Bo Kong
ResearchOpen Access08 Aug 2025
Oncogene

Volume: 44, P: 3774-3786
QBEmax is a sequence-permuted and internally protected base editor

A base editor designed using circular permutation reduces off-target effects while enhancing purity.

Jiacheng Hu
Mengyue Guo
Kevin Tianmeng Zhao
ResearchOpen Access21 Apr 2025
Nature Biotechnology

P: 1-7
Visualizing RNA dynamics in live cells with bright and stable fluorescent RNAs

A series of bright fluorescent RNAs with a broad emission spectra enable live cell imaging of RNA dynamics.

Xianjun Chen
Dasheng Zhang
Yi Yang
Research23 Sept 2019
Nature Biotechnology

Volume: 37, P: 1287-1293
DS2 designer pre-fusion F vaccine induces strong and protective antibody response against RSV infection

Yiling Yang
Ruoke Wang
Linqi Zhang
ResearchOpen Access31 Dec 2024
npj Vaccines

Volume: 9, P: 1-12
Identifying metabolic reprogramming phenotypes with glycolysis-lipid metabolism discoordination and intercellular communication for lung adenocarcinoma metastasis

Transcriptomic analysis from lung adenocarcinoma identified an 11-gene signature that could classify metabolic reprogramming phenotypes in patients.

Xin Li
Lefan Tang
Xia Li
ResearchOpen Access17 Mar 2022
Communications Biology

Volume: 5, P: 1-13
Targeting HDAC/OAZ1 axis with a novel inhibitor effectively reverses cisplatin resistance in non-small cell lung cancer

Yuhong Sun
Xuefei Bao
Lihui Wang
ResearchOpen Access24 May 2019
Cell Death & Disease

Volume: 10, P: 1-13
Ubiquitin specific peptidase 11 as a novel therapeutic target for cancer management

Yihao Liao
Diansheng Zhou
Ning Jiang
ReviewsOpen Access17 Jun 2022
Cell Death Discovery

Volume: 8, P: 1-12