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Showing 1–6 of 6 results
Advanced filters: Author: Mengze Lyu Clear advanced filters

  • RORγt+ antigen-presenting cells (APC) are playing a role in the generation of oral tolerance via their interaction with regulatory T cells recognising dietary and commensal bacterial antigens. Here authors show that a cis transcriptional regulatory element is responsible for RORγt specifically in APCs through interaction with RUNX3 and formation of chromatin loops, which determines a transcriptional program that distinguishes these oral tolerance mediating APCs from RORγt + T cells.

    • Jie Zhao
    • Jiacheng Hao
    • Xiaohuan Guo
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-18

  • Subsets of ILC3s upregulate the immunoregulatory checkpoint molecule CTLA-4 after stimulation in a microbiota-dependent manner, and advances to support CTLA-4+ ILC3s may represent a treatment opportunity in IL-23-driven chronic inflammation.

    • Anees Ahmed
    • Ann M. Joseph
    • Gregory F. Sonnenberg
    Research
    Nature
    Volume: 630, P: 976-983

  • Recent studies have revealed a family of antigen-presenting cells (APCs) marked by the transcription factor RORγt that fundamentally shape immunity, inflammation and tolerance. This article reviews heterogeneity among RORγt+ APCs, their associated functions and the future promise of this new field.

    • Jakub Abramson
    • Jan Dobeš
    • Gregory F. Sonnenberg
    Reviews
    Nature Reviews Immunology
    Volume: 24, P: 64-77