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Showing 1–8 of 8 results
Advanced filters: Author: Meriem Belabed Clear advanced filters

  • An understanding of the molecular mechanisms promoting the generation of immunoregulatory and tumour-promoting monocytes and macrophages is key to breaking the cycle of tumour myelopoiesis and developing more effective myeloid-targeting therapies.

    • Samarth Hegde
    • Bruno Giotti
    • Miriam Merad
    Research
    Nature
    Volume: 646, P: 1214-1222

  • Single-cell transcriptomics studies on human and mouse non-small cell lung cancer and conditional knockout mouse models show that IL-4 from bone marrow basophils drives the development of granulocyte-monocyte progenitors to myeloid cells that suppress antitumour immunity.

    • Nelson M. LaMarche
    • Samarth Hegde
    • Miriam Merad
    Research
    Nature
    Volume: 625, P: 166-174

  • In non-small cell lung cancer, the presence of monocyte-derived macrophages inversely correlates with the presence of NK cells. Merad and colleagues propose that when monocytes phagocytose tumor debris they express TREM2, become pro-tumorigenic, and suppress NK cell recruitment and activation in tumors.

    • Matthew D. Park
    • Ivan Reyes-Torres
    • Miriam Merad
    Research
    Nature Immunology
    Volume: 24, P: 792-801

  • Kinesin-1 is a motor protein transporting cargo along microtubules. Here the authors show that kinesin-1 is required for antigen cross-presentation and coordinates endosome scission from early endosomes to allow sorting internalized cargoes towards the recycling endosomal or lysosomal compartments.

    • Meriem Belabed
    • François-Xavier Mauvais
    • Gaël Ménasché
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Dendritic cells (DCs) shape the adaptive immune response to peripheral tissue antigens and, as such, are crucial for mounting an effective antitumour immune response in cancer. This Review outlines the molecular basis of DC maturation, highlights the mechanisms through which cancer impairs DC maturation and considers the potential for DC-focused cancer immunotherapeutics.

    • Chang Yoon Moon
    • Meriem Belabed
    • Miriam Merad
    Reviews
    Nature Reviews Cancer
    Volume: 25, P: 225-248

  • This Comment article from the Precision Immunology Institute at the Icahn School of Medicine (PrIISM), New York, describes their efforts to provide critical reviews of COVID-19 articles posted daily on the preprint servers bioRxiv and medRxiv.

    • Nicolas Vabret
    • Robert Samstein
    • Uri Laserson
    Comments & Opinion
    Nature Reviews Immunology
    Volume: 20, P: 338