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Showing 1–2 of 2 results
Advanced filters: Author: Merrin Man-Long Leong Clear advanced filters

  • The dynamic and temporal changes of host genome architecture during Epstein-Barr virus (EBV) transformation are not well known. Here the authors transform human primary B lymphocyte into lymphoblastoid cell lines (LCLs) with EBV and show that the host 3D genome is rewired to facilitate expression of key oncogenes.

    • Chong Wang
    • Xiang Liu
    • Bo Zhao
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Here the authors report a major histocompatibility complex (MHC) association analysis for nasopharyngeal carcinoma in Chinese individuals from Hong Kong, finding 8 independent associated loci associated with lower risk for developing nasopharyngeal carcinoma. Two non-human leukocyte antigen (HLA) genes are E3 ubiquitin ligases, TRIM31 and TRIM39, having a role in the innate immune response and implicating the importance of host Epstein-Barr virus interactions in this cancer.

    • Lvwen Ning
    • Josephine Mun-Yee Ko
    • Maria Li Lung
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-13