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Showing 1–4 of 4 results

Advanced filters: Author: Miaohui Hu Clear advanced filters

Non-equilibrium snapshots of ligand efficacy at the μ-opioid receptor

Michael J. Robertson
Arnab Modak
Georgios Skiniotis
Research22 Dec 2025
Nature

P: 1-3
Structures of the R-type human Ca_v2.3 channel reveal conformational crosstalk of the intracellular segments

Voltage-gated Ca2+ channel subtype Cav2.3 represents a potential drug target for neurological diseases. Here, authors report cryo-EM structures of Cav2.3 and its mutant to reveal the crosstalk of intracellular segments, which may facilitate future drug discovery.

Xia Yao
Yan Wang
Nieng Yan
ResearchOpen Access30 Nov 2022
Nature Communications

Volume: 13, P: 1-11
Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm

Hedgehog (Hh) controls embryonic development via interaction with its receptor Patched (Ptch). Here the authors report the cryo-EM structure of tetrameric Ptch1 in complex with the palmitoylated N-terminal signaling domain of human Sonic hedgehog (ShhNp) at a 4:2 stoichiometric ratio.

Hongwu Qian
Pingping Cao
Xin Gong
ResearchOpen Access24 May 2019
Nature Communications

Volume: 10, P: 1-9
Pore architecture of TRIC channels and insights into their gating mechanism

X-ray structures of C. elegans TRIC-B subtype channels reveal that the membrane proteins form a symmetrical homotrimeric complex, and a mechanistic model to explain the complex gating mechanism of TRIC channels is proposed.

Hanting Yang
Miaohui Hu
Zhenfeng Liu
Research03 Oct 2016
Nature

Volume: 538, P: 537-541