Nature Search

A lower X-gate in TASK channels traps inhibitors within the vestibule

The X-ray crystal structure of the potassium channel TASK-1 reveals the presence of an X-gate, which traps small-molecule inhibitors in the intramembrane vestibule and explains their low washout rates from the channel.

Karin E. J. Rödström
Aytuğ K. Kiper
Elisabeth P. Carpenter
Research29 Apr 2020
Nature

Volume: 582, P: 443-447
Action of Blue Light on the Germination of Seeds

MICHAEL EVENARI
GERT NEUMANN
GABRIEL STEIN
Research21 Sept 1957
Nature

Volume: 180, P: 609-610
Gain-of-function mutations in KCNK3 cause a developmental disorder with sleep apnea

Heterozygous de novo gain-of-function mutations in KCNK3, which encodes the two-pore-domain K⁺ channel TASK-1, cause a channelopathy characterized by developmental delay with sleep apnea.

Janina Sörmann
Marcus Schewe
Stephen J. Tucker
ResearchOpen Access04 Oct 2022
Nature Genetics

Volume: 54, P: 1534-1543
Photon-statistics force in ultrafast electron dynamics

Strong-field approximation theory is extended to account for non-classical driving light. This extended theory predicts that ultrafast dynamics of strongly light-driven matter significantly depends on the quantum state of the driving light, particularly on its photon statistics.

Matan Even Tzur
Michael Birk
Oren Cohen
Research05 Jun 2023
Nature Photonics

Volume: 17, P: 501-509
Effects of Thyroid Hormone on Myocardial Adrenergic β-Receptor Responsiveness and Function during Late Gestation

Einat Birk
Michael R Tyndall
James M Roberts
Research01 May 1992
Pediatric Research

Volume: 31, P: 468-473
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

Stig Bojesen, Georgia Chenevix-Trench, Alison Dunning and colleagues report common variants at the TERT-CLPTM1L locus associated with mean telomere length measured in whole blood. They also identify associations at this locus to breast or ovarian cancer susceptibility and report functional studies in breast and ovarian cancer tissue and cell lines.

Stig E Bojesen
Karen A Pooley
Alison M Dunning
Research27 Mar 2013
Nature Genetics

Volume: 45, P: 371-384
SUMO protease SENP1 induces isomerization of the scissile peptide bond

Linnan Shen
Michael H Tatham
Ronald T Hay
Research12 Nov 2006
Nature Structural & Molecular Biology

Volume: 13, P: 1069-1077
A possible function for thaumatin and a TMV-induced protein suggested by homology to a maize inhibitor

Michael Richardson
Silvia Valdes-Rodriguez
Alejandro Blanco-Labra
Research04 Jun 1987
Nature

Volume: 327, P: 432-434
An image of the Sunyaev–Zel'dovich effect

Michael Jones
Richard Saunders
Donald Wilson
Research23 Sept 1993
Nature

Volume: 365, P: 320-323
Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

Paul Pharoah and colleagues report the results of a large genome-wide association study of ovarian cancer. They identify new susceptibility loci for different epithelial ovarian cancer histotypes and use integrated analyses of genes and regulatory features at each locus to predict candidate susceptibility genes, including OBFC1.

Catherine M Phelan
Karoline B Kuchenbaecker
Paul D P Pharoah
Research27 Mar 2017
Nature Genetics

Volume: 49, P: 680-691
Correction: Corrigendum: Transcriptional regulator PRDM12 is essential for human pain perception

Ya-Chun Chen
Michaela Auer-Grumbach
Jan Senderek
Amendments and Corrections29 Jul 2015
Nature Genetics

Volume: 47, P: 962
High-harmonic generation by a bright squeezed vacuum

High-harmonic generation has so far been driven only by classical light. Now, its driving by a bright squeezed vacuum—a quantum state of light—has been observed and shown to be more efficient than using classical light.

Andrei Rasputnyi
Zhaopin Chen
Francesco Tani
ResearchOpen Access02 Oct 2024
Nature Physics

Volume: 20, P: 1960-1965
A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Breast cancer risk for BRCA1/BRCA2 mutation carriers varies depending on other genetic factors. Here, the authors perform a case-only genome-wide association study and highlight novel loci associated with breast cancer risk for BRCA1/BRCA2 mutation carriers.

Juliette Coignard
Michael Lush
Antonis C. Antoniou
ResearchOpen Access17 Feb 2021
Nature Communications

Volume: 12, P: 1-22
Stickler syndrome: further mutations in COL11A1 and evidence for additional locus heterogeneity

Sam Martin
Allan J Richards
Martin P Snead
Research16 Nov 1999
European Journal of Human Genetics

Volume: 7, P: 807-814
Inhibition of demethylases by GSK-J1/J4

Bo Heinemann
Jesper Morten Nielsen
Kristian Helin
Research01 Oct 2014
Nature

Volume: 514, P: E1-E2
A microparticulate based formulation to protect therapeutic enzymes from proteolytic digestion: phenylalanine ammonia lyase as case study

Irene Pereira de Sousa
Charlotte Gourmel
Jean-Christophe Leroux
ResearchOpen Access27 Feb 2020
Scientific Reports

Volume: 10, P: 1-11
SARS-CoV-2 Omicron boosting induces de novo B cell response in humans

COVID-19 booster immunizations aimed at spike protein from new SARS-CoV-2 variants induce robust germinal centre B cell responses against the original spike protein, as well as de novo B cell responses against the variant spike protein.

Wafaa B. Alsoussi
Sameer Kumar Malladi
Ali H. Ellebedy
Research03 Apr 2023
Nature

Volume: 617, P: 592-598
High-harmonic generation driven by quantum light

High-harmonic generation is a source of high-frequency radiation and is typically driven by strong, but classical, laser fields. A theoretical study now shows that using quantum light states as the driver extends the spectrum of outgoing radiation in a controllable manner.

Alexey Gorlach
Matan Even Tzur
Ido Kaminer
Research03 Aug 2023
Nature Physics

Volume: 19, P: 1689-1696
Subgenual prefrontal cortex abnormalities in mood disorders

Wayne C. Drevets
Joseph L. Price
Marcus E. Raichle
Research24 Apr 1997
Nature

Volume: 386, P: 824-827
Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer

Oestrogen negative breast cancer is associated with a poor prognosis. In this study, the authors perform a meta-analysis of 11 breast cancer genome-wide association studies and identify four new loci associated with oestrogen negative breast cancer risk. These findings may aid in stratifying patients in the clinic.

Fergus J. Couch
Karoline B. Kuchenbaecker
Antonis C. Antoniou
ResearchOpen Access27 Apr 2016
Nature Communications

Volume: 7, P: 1-13
Single-cell analysis identifies the CNP/GC-B/cGMP axis as marker and regulator of modulated VSMCs in atherosclerosis

The second messenger 3’,5’-cyclic guanosine monophosphate (cGMP) is important for the maintenance of cardiovascular homeostasis. Here, correlative single-cell profiling of cGMP dynamics and vascular cell phenotype reveals a druggable atheroprotective mechanism and suggests parallels between remodeling processes in bone and atherosclerotic arteries.

Moritz Lehners
Hannes Schmidt
Robert Feil
ResearchOpen Access15 Jan 2025
Nature Communications

Volume: 16, P: 1-21
Exploratory analysis of eating- and physical activity-related outcomes from a randomized controlled trial for weight loss maintenance with exercise and liraglutide single or combination treatment

Weight regain after weight loss is a challenge in obesity treatment and may involve altered eating and sedentary behaviour after weight loss. Here the authors report an exploratory analysis of eating- and physical activity-related outcomes from a randomized controlled trial for weight loss maintenance with exercise and liraglutide single or combination treatment.

Simon Birk Kjær Jensen
Charlotte Janus
Signe Sørensen Torekov
ResearchOpen Access15 Aug 2022
Nature Communications

Volume: 13, P: 1-11
Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

Roger Milne and colleagues conduct a genome-wide association study for estrogen receptor (ER)-negative breast cancer combined with BRCA1 mutation carriers in a large cohort. They identify ten new risk variants and find high genetic correlation between breast cancer risk for BRCA1 mutation carriers and risk of ER-negative breast cancer in the general population.

Roger L Milne
Karoline B Kuchenbaecker
Jacques Simard
Research23 Oct 2017
Nature Genetics

Volume: 49, P: 1767-1778
Autosomal recessive Adams–Oliver syndrome caused by homozygous mutation in EOGT, encoding an EGF domain-specific O-GlcNAc transferase

Idan Cohen
Eldad Silberstein
Ohad S Birk
Research17 Jul 2013
European Journal of Human Genetics

Volume: 22, P: 374-378
Skeletal muscle from TBC1D4 p.Arg684Ter variant carriers is severely insulin resistant but exhibits normal metabolic responses during exercise

In Greenlandic Inuit, a TBC1D4 loss-of-function mutation increases type 2 diabetes risk by tenfold. Carriers show severe muscle insulin resistance, impaired glucose disposal and reduced muscle GLUT4, yet exercise mitigates these defects, offering potential for personalized lifestyle interventions.

Jonas M. Kristensen
Rasmus Kjøbsted
Jørgen F. P. Wojtaszewski
ResearchOpen Access31 Oct 2024
Nature Metabolism

Volume: 6, P: 2254-2266
Human and Rabbit Newborn Lung Macrophages Have Reduced Anti-Candida Activity

John B D'Ambola
Michael P Sherman
Henry Gong Jr.
Research01 Sept 1988
Pediatric Research

Volume: 24, P: 285-290
Ontogeny of Surfactant Proteins A and B in Human Amniotic Fluid as Indices of Fetal Lung Maturity

Gloria S Pryhuber
William M Hull
Jeffrey A Whitsett
Research01 Dec 1991
Pediatric Research

Volume: 30, P: 597-605
Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Juliette Coignard
Michael Lush
Antonis C. Antoniou
Amendments and CorrectionsOpen Access14 May 2021
Nature Communications

Volume: 12, P: 1-2
Cre/lox-assisted non-invasive in vivo tracking of specific cell populations by positron emission tomography

Non-invasive cell tracking is a powerful method to visualize cells in vivo under physiological and pathophysiological conditions. Here Thunemann et al. generate a mouse model for in vivo tracking and quantification of specific cell types by combining a PET reporter gene with Cre-dependent activation that can be exploited for any cell population for which a Cre mouse line is available.

Martin Thunemann
Barbara F. Schörg
Robert Feil
ResearchOpen Access05 Sept 2017
Nature Communications

Volume: 8, P: 1-12
Identification of six new susceptibility loci for invasive epithelial ovarian cancer

Georgia Chenevix-Trench and colleagues report meta-analyses of genome-wide association studies identifying six loci newly associated with epithelial ovarian cancer (EOC). They also test variants at the 12 known and 6 new EOC susceptibility loci for association in BRCA1 and BRCA2 mutation carriers.

Karoline B Kuchenbaecker
Susan J Ramus
Georgia Chenevix-Trench
Research12 Jan 2015
Nature Genetics

Volume: 47, P: 164-171
Transcriptional regulator PRDM12 is essential for human pain perception

Geoffrey Woods, Jan Senderek and colleagues show that biallelic mutations in PRDM12 cause congenital insensitivity to pain. They further show that PRDM12 is expressed in nociceptors and their progenitors and participates in sensory neuron development in Xenopus.

Ya-Chun Chen
Michaela Auer-Grumbach
Jan Senderek
Research25 May 2015
Nature Genetics

Volume: 47, P: 803-808
Anomalous Nernst effect in the noncollinear antiferromagnet Mn₅Si₃

Mn₅Si₃ is an interesting metallic compound that exhibits several antiferromagnetic phases with different collinear and noncollinear arrangements of magnetic moments. Here, anomalous Nernst effect measurements across the magnetic transitions are reported, indicating a symmetry-breaking modification of the magnetic state at low temperatures, in contrast to previous symmetry analysis.

Christoph Sürgers
Gerda Fischer
Wolfgang Wernsdorfer
ResearchOpen Access30 Aug 2024
Communications Materials

Volume: 5, P: 1-9
Multi-decadal groundwater observations reveal surprisingly stable levels in southwestern Europe

Analysis of multi-decadal groundwater level data shows 68% of wells in southwestern Europe are stable, 20% rising, and only 12% declining, and suggests improved management and increased precipitation aid recovery, while agricultural and urban pressures drive decline.

Rafael Chávez García Silva
Robert Reinecke
Seifeddine Jomaa
ResearchOpen Access18 Jul 2024
Communications Earth & Environment

Volume: 5, P: 1-10
The predictive ability of the 313 variant–based polygenic risk score for contralateral breast cancer risk prediction in women of European ancestry with a heterozygous BRCA1 or BRCA2 pathogenic variant

Inge M. M. Lakeman
Alexandra J. van den Broek
Marjanka K. Schmidt
ResearchOpen Access10 Jun 2021
Genetics in Medicine

Volume: 23, P: 1726-1737
X-linked C1GALT1C1 mutation causes atypical hemolytic uremic syndrome

Noam Hadar
Ruth Schreiber
Ohad S. Birk
Research04 Jan 2023
European Journal of Human Genetics

Volume: 31, P: 1101-1107
Author Correction: Highly accurate determination of heterogeneously stacked Van-der-Waals materials by optical microspectroscopy

Andreas Hutzler
Birk Fritsch
Mathias Rommel
Amendments and CorrectionsOpen Access25 Jan 2023
Scientific Reports

Volume: 13, P: 1
Characterization of Mucosal Dysbiosis of Early Colonic Neoplasia

Bo-young Hong
Takayasu Ideta
Daniel W. Rosenberg
ResearchOpen Access14 Nov 2019
npj Precision Oncology

Volume: 3, P: 1-10
Highly accurate determination of heterogeneously stacked Van-der-Waals materials by optical microspectroscopy

Andreas Hutzler
Birk Fritsch
Mathias Rommel
ResearchOpen Access13 Aug 2020
Scientific Reports

Volume: 10, P: 1-8
Intermittent exposure to whole cigarette smoke alters the differentiation of primary small airway epithelial cells in the air-liquid interface culture

Julia A. Gindele
Tobias Kiechle
Jürgen Schymeinsky
ResearchOpen Access10 Apr 2020
Scientific Reports

Volume: 10, P: 1-17
Identification of a rare BMP pathway mutation in a non-syndromic human brain arteriovenous malformation via exome sequencing

Brian P Walcott
Ethan A Winkler
Michael T Lawton
ResearchOpen Access08 Mar 2018
Human Genome Variation

Volume: 5, P: 1-9
Submillimeter Ultra-High Field 9.4 T Brain MR Image Collection and Manual Cortical Segmentations

Lucas Mahler
Julius Steiglechner
Klaus Scheffler
ResearchOpen Access15 Apr 2025
Scientific Data

Volume: 12, P: 1-9
The political economy of climate adaptation

Initiatives to adapt to the effects of climate change are growing in number but may fail to achieve the desired outcomes unless critical competing interests are taken into account during the planning process.

Benjamin K. Sovacool
Björn-Ola Linnér
Michael E. Goodsite
Comments & Opinion24 Jun 2015
Nature Climate Change

Volume: 5, P: 616-618

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