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Showing 1–50 of 155 results

Advanced filters: Author: Michael D. Enos Clear advanced filters

Developmental Expression of Endothelial Nitric Oxide Synthase (eNOS) in the Rat Liver

Michael J Nowicki
Dongping Shi
Warren L May
Research01 Nov 2003
Pediatric Research

Volume: 54, P: 732-738
Zeb1-Hdac2-eNOS circuitry identifies early cardiovascular precursors in naive mouse embryonic stem cells

The production of nitric oxide (NO) is required for early stage embryo implantation into the uterus. Here the authors show that during differentiation of naive mouse ESCs, early production of endogenous NO leads to a mesendoderm differentiation commitment pathway by inhibiting the action of the transcriptional repressor Zeb1.

Chiara Cencioni
Francesco Spallotta
Carlo Gaetano
ResearchOpen Access29 Mar 2018
Nature Communications

Volume: 9, P: 1-15
High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase

Ivan S. Yuhanna
Yan Zhu
Philip W. Shaul
Research01 Jul 2001
Nature Medicine

Volume: 7, P: 853-857
Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase

Ali Hafezi-Moghadam
Tommaso Simoncini
James K. Liao
Research01 May 2002
Nature Medicine

Volume: 8, P: 473-479
Hypertension in mice lacking the gene for endothelial nitric oxide synthase

Paul L. Huang
Zhihong Huang
Mark C. Fishman
Research21 Sept 1995
Nature

Volume: 377, P: 239-242
Posttranslational Activation of Endothelial Nitric Oxide Synthase Attenuates Carbon Tetrachloride-Induced Hepatotoxicity in Newborn Rats

Hua Liu
Charu Subramony
Michael Nowicki
Research01 Jun 2008
Pediatric Research

Volume: 63, P: 613-619
Phospholipase D2 loss results in increased blood pressure via inhibition of the endothelial nitric oxide synthase pathway

Rochelle K. Nelson
Jiang Ya-Ping
Michael A. Frohman
ResearchOpen Access22 Aug 2017
Scientific Reports

Volume: 7, P: 1-13
EP4 inhibition attenuates the development of diabetic and non-diabetic experimental kidney disease

Karina Thieme
Syamantak Majumder
Andrew Advani
ResearchOpen Access13 Jun 2017
Scientific Reports

Volume: 7, P: 1-11
Expression of Nitric Oxide Synthases and Nitrotyrosine during Blood-Brain Barrier Breakdown and Repair after Cold Injury

Sukriti Nag
Pierre Picard
Duncan J Stewart
Research01 Jan 2001
Laboratory Investigation

Volume: 81, P: 41-49
Pluripotency factors functionally premark cell-type-restricted enhancers in ES cells

Binding of an embryonic stem in two cases cell-specific transcription factor pre-marks cell-type-restricted enhancers in embryonic stem in two cases cells, and this premarking is required for the robustness of enhancer activation in differentiated cells.

Hong Sook Kim
Yuliang Tan
Michael G. Rosenfeld
Research18 Apr 2018
Nature

Volume: 556, P: 510-514
Increased CSF drainage by non-invasive manipulation of cervical lymphatics

The outflow pathway of cerebrospinal fluid into lymph nodes in the neck and how non-invasive mechanical stimulation can enhance drainage and restore impaired outflow in aged mice are explored.

Hokyung Jin
Jin-Hui Yoon
Gou Young Koh
ResearchOpen Access04 Jun 2025
Nature

Volume: 643, P: 755-767
Pleiotropic activation of endothelial function by angiotensin II receptor blockers is crucial to their protective anti-vascular remodeling effects

Arash Y. Tehrani
Zoe White
Pascal Bernatchez
ResearchOpen Access13 Jun 2022
Scientific Reports

Volume: 12, P: 1-14
Angiotensin II Regulates NOS Expression in Afferent Arterioles of the Developing Porcine Kidney

Brian B Ratliff
Miroslav Sekulic
Michael J Solhaug
Research01 Jul 2010
Pediatric Research

Volume: 68, P: 29-34
Alterations in Nitric Oxide Production in 8-Week-Old Lambs with Increased Pulmonary Blood Flow

Stephen M Black
Janine M Bekker
Jeffrey R Fineman
Research01 Aug 2002
Pediatric Research

Volume: 52, P: 233-244
Prenatal inflammation-induced NF-κB dyshomeostasis contributes to renin-angiotensin system over-activity resulting in prenatally programmed hypertension in offspring

Youcai Deng
Yafei Deng
Xiaohui Li
ResearchOpen Access15 Feb 2016
Scientific Reports

Volume: 6, P: 1-17
A smoking–dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene

Xing L. Wang
Ah Siew Sim
David E.L. Wilcken
Research01 Jan 1996
Nature Medicine

Volume: 2, P: 41-45
Somatic cell hemoglobin modulates nitrogen oxide metabolism in the human airway epithelium

Nadzeya Marozkina
Laura Smith
Benjamin Gaston
ResearchOpen Access29 Jul 2021
Scientific Reports

Volume: 11, P: 1-11
Caveolin-1 modulates intraocular pressure: implications for caveolae mechanoprotection in glaucoma

Michael H. Elliott
Nicole E. Ashpole
W. Daniel Stamer
ResearchOpen Access14 Nov 2016
Scientific Reports

Volume: 6, P: 1-12
Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis

Sina M. Coldewey
Elisa Benetti
Christoph Thiemermann
ResearchOpen Access09 Jun 2016
Scientific Reports

Volume: 6, P: 1-12
Cardiac spheroids as promising in vitro models to study the human heart microenvironment

Liudmila Polonchuk
Mamta Chabria
Carmine Gentile
ResearchOpen Access01 Aug 2017
Scientific Reports

Volume: 7, P: 1-12
Effects of Gravitational Mechanical Unloading in Endothelial Cells: Association between Caveolins, Inflammation and Adhesion Molecules

S. Marlene Grenon
Marion Jeanne
Millie Hughes-Fulford
ResearchOpen Access20 Mar 2013
Scientific Reports

Volume: 3, P: 1-8
Cytoglobin regulates NO-dependent cilia motility and organ laterality during development

Developmental defects in left-right cardiac determination in humans are associated with ciliary dysfunction and low airway epithelial nitric oxide production. Here, the authors show that cytoglobin is essential for nitric oxide signaling, cilia function, and left-right patterning during zebrafish development.

Elizabeth R. Rochon
Jianmin Xue
Paola Corti
ResearchOpen Access14 Dec 2023
Nature Communications

Volume: 14, P: 1-13
Automated in vivo compound screening with zebrafish and the discovery and validation of PD 81,723 as a novel angiogenesis inhibitor

Antonio N. Mauro
Paul J. Turgeon
Krishna K. Singh
ResearchOpen Access25 Aug 2022
Scientific Reports

Volume: 12, P: 1-17
Dapagliflozin prevents vascular ischemia-reperfusion injury in healthy young males: a randomized, placebo-controlled, double-blinded trial

Martin Lutnik
Stefan Weisshaar
Michael Wolzt
ResearchOpen Access13 May 2025
Scientific Reports

Volume: 15, P: 1-10
Coordinated Regulation of Genes of the Nitric Oxide and Endothelin Pathways during the Development of Pulmonary Hypertension in Fetal Lambs

Stephen M Black
Michael J Johengen
Scott J Soifer
Research01 Dec 1998
Pediatric Research

Volume: 44, P: 821-830
Varied effects of tobacco smoke and e-cigarette vapor suggest that nicotine does not affect endothelium-dependent relaxation and nitric oxide signaling

Gerald Wölkart
Alexander Kollau
Bernd Mayer
ResearchOpen Access22 Sept 2023
Scientific Reports

Volume: 13, P: 1-14
Trans-arachidonic acids generated during nitrative stress induce a thrombospondin-1–dependent microvascular degeneration

Elsa Kermorvant-Duchemin
Florian Sennlaub
Sylvain Chemtob
Research27 Nov 2005
Nature Medicine

Volume: 11, P: 1339-1345
The guidance receptor plexin D1 is a mechanosensor in endothelial cells

PLXND1 is a mechanosensor that is required for endothelial cells to respond to shear stress both in vitro and in vivo by regulating the site-specific distribution of atherosclerotic lesions.

Vedanta Mehta
Kar-Lai Pang
Ellie Tzima
Research05 Feb 2020
Nature

Volume: 578, P: 290-295
Mechanisms, challenges and opportunities in stroke

Eng H. Lo
Turgay Dalkara
Michael A. Moskowitz
Reviews01 May 2003
Nature Reviews Neuroscience

Volume: 4, P: 399-414
Caveolae and signalling in cancer

Caveolar lipid rafts are distinct regions of the cell membrane that can mediate diverse signalling events, including the regulation of autophagy, responses to oxidative stress and metabolism. What are the implications of caveolae in cancer cells and associated stromal cells?

Ubaldo E. Martinez-Outschoorn
Federica Sotgia
Michael P. Lisanti
Reviews24 Mar 2015
Nature Reviews Cancer

Volume: 15, P: 225-237
Fetal and postnatal ovine mesenteric vascular reactivity

Jayasree Nair
Sylvia F. Gugino
Satyan Lakshminrusimha
Research16 Dec 2015
Pediatric Research

Volume: 79, P: 575-582
The soluble guanylate cyclase stimulator riociguat reduces fibrogenesis and portal pressure in cirrhotic rats

Philipp Schwabl
Ksenia Brusilovskaya
Thomas Reiberger
ResearchOpen Access19 Jun 2018
Scientific Reports

Volume: 8, P: 1-13
Lithocholic acid facilitates release of angiocrine factors by liver sinusoidal endothelial cells during liver regeneration

Impreet Kaur
Aarti Sharma
Savneet Kaur
ResearchOpen Access30 Sept 2025
npj Gut and Liver

Volume: 2, P: 1-13
Molecular patterns of the NO-sGC-cGMP pathway in progressive and regressive liver fibrosis models

Thomas Sorz-Nechay
Ksenia Brusilovskaya
Thomas Reiberger
ResearchOpen Access25 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
The role of endothelial HIF-1 αin the response to sublethal hypoxia in C57BL/6 mouse pups

Qi Li
Michael Michaud
Joseph A Madri
Research16 Jan 2017
Laboratory Investigation

Volume: 97, P: 356-369
Erythropoietin-induced upregulation of endothelial nitric oxide synthase but not vascular endothelial growth factor prevents musculocutaneous tissue from ischemic damage

Farid Rezaeian
Reto Wettstein
Yves Harder
Research09 Nov 2009
Laboratory Investigation

Volume: 90, P: 40-51
Implantable niche with local immunosuppression for islet allotransplantation achieves type 1 diabetes reversal in rats

Islet transplantation for type 1 diabetes management is hindered by the life-long need for immunosuppressive medications. Here, the authors report an islet encapsulation device with local anti-rejection drug release that achieves long-term diabetes reversal in male rats and reduces drug-related toxicity.

Jesus Paez-Mayorga
Jocelyn Nikita Campa-Carranza
Alessandro Grattoni
ResearchOpen Access26 Dec 2022
Nature Communications

Volume: 13, P: 1-20
SNO-hemoglobin is not essential for red blood cell–dependent hypoxic vasodilation

T Scott Isbell
Chiao-Wang Sun
Tim M Townes
Research30 May 2008
Nature Medicine

Volume: 14, P: 773-777
Maslinic acid alleviates ischemia/reperfusion-induced inflammation by downregulation of NFκB-mediated adhesion molecule expression

Emmanuel Ampofo
Julian J. Berg
Matthias W. Laschke
ResearchOpen Access16 Apr 2019
Scientific Reports

Volume: 9, P: 1-13
A tough nitric oxide-eluting hydrogel coating suppresses neointimal hyperplasia on vascular stent

Neointimal hyperplasia and stent thrombosis remain issues with vascular stents. Here, the authors report on the development of a nitric oxide releasing hydrogel which allows for endothelialisation of the stent surface and prevents smooth muscle cell growth reducing hyperplasia and thrombosis in in vivo models.

Yin Chen
Peng Gao
Hongkai Wu
ResearchOpen Access06 Dec 2021
Nature Communications

Volume: 12, P: 1-16
PR39, a peptide regulator of angiogenesis

Jian Li
Mark Post
Michael Simons
Research01 Jan 2000
Nature Medicine

Volume: 6, P: 49-55
The role of conformational entropy in molecular recognition by calmodulin

NMR-measured order parameters of methyl groups can be used to quantitate the entropy of protein conformational change associated with calmodulin-peptide ligand interactions. This conformational entropy is a major contributor to the affinity of calmodulin interactions.

Michael S Marlow
Jakob Dogan
A Joshua Wand
Research11 Apr 2010
Nature Chemical Biology

Volume: 6, P: 352-358
ESTIMATION OF SUBENDOCARDIAL ISCHEMIA IN VALVAR AORTIC STENOSIS IN CHILDREN

Alan B Lewis
Michael A Heymann
Abraham M Rudolph
Research01 Apr 1974
Pediatric Research

Volume: 8, P: 352
Differential Roles of Estrogen Receptors Alpha and Beta in the Nongenomic Activation of Endothelial Nitric Oxide Synthase by Estradiol

Ken L Chambliss
Ivan S Yuhanna
Philip W Shaul
Research01 Apr 1999
Pediatric Research

Volume: 45, P: 20
Sustained elevation of NF-κB activity sensitizes offspring of maternal inflammation to hypertension via impairing PGC-1α recovery

Yafei Deng
Qi Zhang
Xiaohui Li
ResearchOpen Access12 Sept 2016
Scientific Reports

Volume: 6, P: 1-14
Resveratrol Inhibition of Rac1-Derived Reactive Oxygen Species by AMPK Decreases Blood Pressure in a Fructose-Induced Rat Model of Hypertension

Pei-Wen Cheng
Hui-Chieh Lee
Ching-Jiunn Tseng
ResearchOpen Access03 May 2016
Scientific Reports

Volume: 6, P: 1-12
PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism

Aggressive cerebral cavernous malformations (CCMs) are found to grow through a three-hit cancer-like mechanism, involving gain of function of a gene that promotes vascular growth, and loss of function of genes that suppress it.

Aileen A. Ren
Daniel A. Snellings
Mark L. Kahn
Research28 Apr 2021
Nature

Volume: 594, P: 271-276
Expansion of functional personalized cells with specific transgene combinations

Personalised medicine requires cell cultures from defined genetic backgrounds, but providing sufficient numbers of cells is a challenge. Here the authors develop gene cocktails to expand primary cells from a variety of different tissues and species, and show that expanded endothelial and hepatic cells retain properties of the differentiated phenotype.

Christoph Lipps
Franziska Klein
Tobias May
ResearchOpen Access08 Mar 2018
Nature Communications

Volume: 9, P: 1-12
Protein denitrosylation: enzymatic mechanisms and cellular functions

Protein denitrosylation, the removal of nitric oxide groups from Cys thiols, was once considered to be a spontaneous event. Now, the discovery of denitrosylases, the enzymes that catalyse this process, is advancing our understanding of redox-based signalling in normal and aberrant cellular functions.

Moran Benhar
Michael T. Forrester
Jonathan S. Stamler
Reviews09 Sept 2009
Nature Reviews Molecular Cell Biology

Volume: 10, P: 721-732
Pathology-oriented multiplexing enables integrative disease mapping

Pathology-oriented multiplexing (PathoPlex) represents a framework for widespread access to multiplexed imaging and computational image analysis of clinical specimens at a relatively high throughput and subcellular resolution.

Malte Kuehl
Yusuke Okabayashi
Victor G. Puelles
ResearchOpen Access18 Jul 2025
Nature

Volume: 644, P: 516-526

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